Tobias Schmidt

• Led a team of research scientists in target identification and validation for T-cell mediated anti-tumor immunity and antigen presentation Established and optimized forward genetic screens and gene editing techniques to accelerate target discovery and validation. • Successfully led several small and large molecule projects target discovery projects, resulting in several patents. • Mentored and developed the talent of scientists, research associates, students, and apprentices, resulting in a high-performing and motivated team.

• Conducted target discovery and validation using big data and gene editing techniques in the Target Sciences department, focusing on synthetic lethality, inflammatory lung disease, and viral infections. • Designed, executed, and analyzed CRISPR screens to identify novel targets and validate them in disease-relevant models

• Dissected nucleic acid sensing and LPS recognition as part of the innate immune response • Focused on the relevant receptors/pathways: cGAS, Sting, RigI, Inflammasomes • Build a gene editing and forward genetic screening platform for target discovery