Sarani Ghoshal, PhD, PMP

Senior Project Consultant

About

-PhD-trained scientific leader and PMP-certified project manager with 10+ years of experience driving preclinical and translational programs across biotech R&D -I specialize in turning scientific strategy into well-executed, CRO-driven studies that move programs forward with rigor, clarity, and speed. -My background spans in vitro and in vivo study design, CRO management, cross-functional coordination, and nonclinical portfolio execution, partnering closely with biology, toxicology, DMPK, CMC, regulatory, and program teams. What I do best: Lead outsourced GLP and non-GLP preclinical studies from concept through final report Serve as primary interface with CROs, academic partners, and vendors Translate development strategy into executable plans, timelines, and budgets Maintain inspection-ready documentation and regulatory-aligned study oversight Drive alignment across scientific, operational, and financial stakeholders I thrive in fast-paced, matrixed environments. Open to full-time, contract, or short-term roles in preclinical development, translational science, or scientific project leadership. 📍 Greater Boston / Cambridge, MA | Onsite, Hybrid, Remote

Country

United States

City

Boston

Industry

Research

Skill

Good Laboratory Practice (GLP), Risk Assessment, Operational Planning, Metabolic Diseases, Project Coordination, Team Mentoring, Cross-functional Collaborations, High Throughput Screening, Targeted Drug Delivery, Mentoring, Consulting, Strategic Planning, Early-Stage Startups, Assay Development , CRO Oversight & Vendor Management , SOW / Contract Management , Risk & Issue Management , Cross-functional Team Leadership , Scientific Communications, Metabolomics

Experience

Senior Project Consultant

Prism Helix Innovations

2023-5 - Present · 3 yrs 4 mos

-Provided project-based scientific and operational support across preclinical research, program planning, and scientific communications -Supported short-term advisory, nonprofit, and science-led initiatives

Principal Scientist

HC Bioscience, Inc. (operation closed)

2022-3 - 2023-3 · 1 yr 1 mo

-Oversaw outsourced in vitro and in vivo studies including toxicology, biodistribution, and efficacy studies -Developed study concepts, reviewed protocols, SOWs, and CRO proposals; negotiated timelines and budgets -Acted as primary CRO contact, monitoring execution, resolving issues, and ensuring on-time, high-quality data delivery -Maintained complete study documentation using ELN and tracked milestones using Smartsheet / MS Project -Supported investment planning, forecasting, PO/invoice processing, and vendor performance tracking

Senior Scientist

Korro Bio, Inc.

2020-9 - 2022-2 · 1 yr 6 mos

-Led discovery-stage research in RNA editing, contributing original scientific insight to program direction and experimental strategy -Designed and executed cell-based and in vivo studies to test biological hypotheses and therapeutic mechanisms -Partnered closely with cross-functional scientists to interpret data and refine research direction

Scientist II

Synlogic

2019-3 - 2020-5 · 1 yr 3 mos

Cambridge, MA

-Developed and characterized animal models for hyperoxaluria (mouse and NHP) -Identified, established and validated biomarker assays for hyperoxaluria -Identified CRO partners, designed and executed NHP studies with them to demonstrate the reduction in biomarkers of hyperoxaluria after treatment with engineered bacteria -Designed and executed preclinical studies for PKU: safety, efficacy, PK/PD, PoC to IND enabling

Postdoctoral Research Fellow

Uniformed Services University, Bethesda, MD and Harvard Medical School/Mass General Hospital

2014-6 - 2019-3 · 4 yrs 10 mos

Greater Boston Area

-Developed and characterized mouse and rat models of NASH, fibrosis and hepatocellular carcinoma -Identified the role of lipid metabolism and Acetyl CoA Carboxylase in the progression of liver diseases -Led multiple projects with industry collaboration. Worked and published with 3 biotech companies (Nimbus Therapeutics, Gilead Sciences, Enanta Pharmaceuticals)

CSIR Research Fellow

IACS, Kolkata and IIT, Kharagpur

2004-11 - 2007-12 · 3 yrs 2 mos

India

-Recipient of prestigious Junior and Senior Research Fellowship from CSIR, Govt of India -Worked on creatine kinase and other mitochondrial proteins in the progression of sarcoma -Contributed to 3 publications

Education

University of Memphis

Molecular Biology

2008-1 - 2013-12 · 6 yrs

-Identified the function of a novel liver enriched mitochondrial protein NIPSNAP1. Characterized NIPSNAP1 knockout mouse -Demonstrated that NIPSNAP1 deficiency caused altered amino acid, lipid and nucleotide metabolism in liver