Sai-Wen Tang
Senior Director of R&D @ Acepodia
About
Ten years of experience in cancer research. Experienced in developing immune cell therapy and utilizing CAR-T technology. Skilled to identify therapeutic targets by analyzing big data sets.
United States
Alameda
Biotechnology
Western Blotting, Molecular Biology, Cancer Research, Cell Culture, Cell Biology, Biochemistry, PCR, Molecular Cloning, Confocal Microscopy, Microscopy, Protein Purification, Protein Expression, Immunohistochemistry, Luciferase Assay, autophagy, Molecular Virology, qPCR, ChIP-seq, Vector Cloning, ELISA
Experience

Postdoc Fellow
1. Analyzed cancer datasets NCI-60, CCLE and TCGA to identify regulatory mechanism for SLFN11. 2. Generated over-expressing cells by lentiviral infection to demonstrate the role of SLFN11 in sensitivity of cancer cells to chemotherapies. 3. Discovered drugs that sensitizing cancer cells to chemotherapies.

Postdoc Fellow at National Institute of Allergy and Infectious Diseases
1. Investigated how human T cell leukemia virus type 1 (HTLV-1) escapes from host autophagic degradation by ex vivo infection system. 2. Identified the proteins interacting with autophagy receptor Tax1bp1 by immunoprecipitation and mass spectrometry analysis.

Postdoc Fellow
1. Constructed full-length cDNA libraries from tumor samples to identify cancer therapeutic targets and biomarkers by high-throughput DNA sequencing. 2. Demonstrated the role of nicotinamide N-methyltransferase (NNMT) in tumor metastasis. 3. Identified critical amino acids for methyltransferase activity of NNMT by X-ray crystallography.
Education
Sai-Wen Tang's Contact Information
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