Min Z.
Associate Director , siRNA Project Team Leader @ Novartis
About
Accomplished scientist and team leader with over 10 years of expertise from early discovery stage to clinical translational studies. Demonstrated success in program leadership, biomarker strategies and assay development for inflammatory, autoimmune, and fibrotic diseases in the biopharmaceutical industry. Skilled in leading cross-functional teams and managing CROs to drive strategic program direction and execution in dynamic, fast-paced environments. Skills and abilities include: • Leadership of cross-functional teams in preclinical discovery, translational medicine, and biomarkers • Biomarker strategy, assay development, and execution for preclinical and clinical programs • Expertise in disease models: in vivo, in vitro, and ex vivo human tissue models • Experience with multiple modalities: siRNA, ASO, small molecules, antibodies, and gene therapy • Preparation of clinical protocols, study reports, and regulatory documents (ODD, IND) • Effective management of CROs, consultants, and internal teams • Strong communication, organizational, and presentation skills
United States
San Diego
Pharmaceuticals
GPCRs, Vascular Biology, Muscle Physiology, In Vivo, Microsoft Office, Microsoft Excel, Data Analysis, Keyboard Shortcuts, Applied Research, High Pressure, Team Management, Biomarker Discovery, Biomarker Development, Primary Cells, Candidate Selection, Thinking Skills, Biotechnology, Genomics, Translational Science, Biopharmaceuticals
Experience
Associate Director , siRNA Project Team Leader
Novartis
San Diego County, California, United States
Associate Director, Translational Science
Zura Bio Limited (Nasdaq: ZURA)
San Diego County, California, United States
• Led biomarker and translational activities supporting Phase 2 clinical trials for antibody therapies targeting systemic sclerosis and hidradenitis suppurativa • Oversaw biomarker and bioanalytical assay development, validation, and execution • Collaborated with clinical development and regulatory teams to prepare clinical protocols, study reports, and regulatory submissions, including ODD and IND applications • Managed CROs and external consultants to ensure project alignment and deliverables
Principal Scientist, immunology & fibrosis, drug discovery and translational medicine
Takeda
San Diego, California, United States
• Directed programs targeting inflammatory, autoimmune, and fibrotic diseases (e.g., IBD, atopic dermatitis) involving GPCR and non-GPCR signaling pathways. • Led cross-functional teams to advance projects from early discovery to clinical development candidate selection, collaborating with biology, chemistry, translational medicine, safety, DMPK, and clinical teams. • Developed strategic plans for target identification, validation, and exploration of new disease indications. • Designed, optimized, and executed biomarker strategies for preclinical and clinical studies. • Managed direct reports, academic collaborations, and CRO partnerships.
Assistant Director, drug discovery
Ionis Pharmaceuticals, Inc.
San Diego County, California, United States
• Project leader of multiple lung diseases (COPD, IPF, Asthma) by antisense oligonucleotide (ASO) and siRNA • Targets identification and validation • Translational Medicine and Biomarker development using human tissues and ex vivo models (preclinical & clinical) • In vitro cell models development and pharmacology studies • In vivo pharmacology and GLP toxicity studies in rodent and non-human primate • Utilize multiple technologies including Ussing Chambers, qPCR, Elisa, IHC, RNAseq
Senior Scientist, drug discovery
Ionis Pharmaceuticals, Inc.
San Diego, CA
Research Scientist 1 & 2, biology and pharmacology
Vertex Pharmaceuticals
Greater San Diego Area
• SMI, CRISPR-Cas9 gene editing & cell therapy for Cystic Fibrosis • In vitro biology and pharmacology • Primary intestinal and airway epithelial cells
Postdoctoral Researcher
University of Illinois Chicago
Greater Chicago Area
• Stem cell and gene therapy for bacterial induced lung injury. • Lineage tracing analysis of endothelial cell regeneration after lung inflammation and injury in mouse • G proteins in embryonic stem cell (ESC) and iPSCs endothelial differentiation
Postdoc fellow
Indiana University School of Medicine
Indianapolis, Indiana Area
• Transcriptional regulation of intestinal smooth muscle gene and contractility • Chromatin remodeling protein in intestinal smooth muscle development.
Education
Indiana University Indianapolis
Physiology, molecular biology
Capital University of Medical Sciences
Physiology
Min Z.'s Contact Information
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