Chun Pong (James) Tam
Principal Scientist @ Beam Therapeutics
About
A nucleic acid process scientist who is committed to science and manufacturing of RNA drug substance. Current research at Beam therapeutics aims to establish a rigorous and high quality process for the synthesis of modified gRNA. Doctoral research aims to elucidate the mechanistic details of nonenzymatic RNA copying, a chemistry-driven process which has been hypothesized to mediate the evolution of functional ribozymes (RNA enzymes) from a pool of randomized RNA strands. Skilled at solid phase RNA synthesis, nucleotide, peptide and heterocyclic chemistry, mechanism-based analogue design, liquid chromatographic methods, NMR and mass spectroscopies, and binding affinity assays.
United States
Cambridge
Biotechnology
Nucleic acids chemistry and synthesis, Liquid Chromatography-Mass Spectrometry (LC-MS), Organic Synthesis, Nuclear Magnetic Resonance (NMR), Scientific Writing, Molecular Biology, Data Analysis, Grant Writing, Isothermal Titration Calorimetry, Circular Dichroism, Microsoft Outlook, Good Manufacturing Practice (GMP), Analytical Chemistry, Process Optimization, Process scale purification
Experience
Principal Scientist
Beam Therapeutics
Cambridge, Massachusetts, United States
Senior Scientist II
Beam Therapeutics
Cambridge, Massachusetts, United States
Senior Scientist I
Beam Therapeutics
Cambridge, Massachusetts, United States
Scientist II
Beam Therapeutics
Cambridge, Massachusetts, United States
Synthesis of high quality gRNA
Scientist, mRNA stability
Moderna Therapeutics
Cambridge, MA
• Responsible for research and development projects that are related to late-phase development of mRNA therapeutics • Detailed structure elucidation studies and mechanistic investigations into oxidative, hydrolytic, photochemical and thermal degradative pathways of mRNA drug substance and drug product • Demonstration of transesterification as the dominant mRNA strand scission mechanism within drug product • Evaluated 100+ small molecule excipients for possible mRNA drug product shelf-life enhancement
Research Associate, Jack W. Szostak laboratory
Massachusetts General Hospital
Greater Boston Area
Graduate Research Assistant, Jack W. Szostak Laboratory
Massachusetts General Hospital
Greater Boston Area
Thesis Title: Nonhydrolyzable Ribonucleotide Phosphoroimidazolide Analogues for Mechanistic Studies of Nonenzymatic RNA Replication
Undergraduate Research Assistant
Shannon S. Stahl Research Group, University of Wisconsin Madison
Madison, Wisconsin Area
Asymmetric synthesis of (+)-CP-99,994
Research Intern
Novartis Insitutes for Biomedical Research
Greater Boston Area
Structure-Based Design and Synthesis of Small Molecule Inhibitors against Hepatitis C Virus NS5A and Human PI4K Proteins as Potential Hepatitis C Therapeutic Strategies
Education
Harvard University
Chemistry and Chemical Biology
University of Wisconsin-Madison
Chemistry
Chun Pong (James) Tam's Contact Information
Phone
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