Charles Semba (仙波), MD
Chief Medical Officer @ Eluminex Biosciences Limited
About
+25 years in therapeutic product development in public (Genentech/Roche, Shire/Takeda) and private companies (SARcode Biosciences, ForSight VISION5, Graybug Vision); small molecules, biologics, sustained-release, drug delivery; ocular surface, glaucoma, retinal diseases and collagen-based medical devices..
United States
Mountain View
Biotechnology
Dermatology, Biotechnology, Clinical Trials, Drug Development, Clinical Development, Pharmaceutical Industry, Medical Devices, Immunology, Biopharmaceuticals, Medicine, Clinical Research, Ophthalmology, Endocrinology, FDA, Medical Affairs, Life Sciences, Lifesciences, GCP, Drug Discovery, Commercialization
Experience
Chief Medical Officer
Eluminex Biosciences Limited
South San Francisco, California, United States
Eluminex Biosciences is a privately-held clinical-stage biotechnology company focused on both global and regional development and commercialization of innovative therapeutics to fulfill unmet medical needs in the treatment and management of vision-threatening diseases.
Board Member
DiaMedica Therapeutics Inc.
Minneapolis, Minnesota, United States
DiaMedica Therapeutics is a clinical-stage biopharmaceutical company committed to changing the treatment paradigm for high-risk pregnancy (preeclampsia, fetal growth restriction), acute ischemic stroke (AIS) and chronic kidney disease (CKD). DiaMedica’s lead candidate DM199 is the first pharmaceutically active recombinant (synthetic) form of the KLK1 protein, an established therapeutic modality for the treatment of preeclampsia, acute ischemic stroke and chronic kidney disease.
Adjunct Professor - Vascular and Interventional Radiology
Stanford University School of Medicine
Stanford, CA
Development of minimally invasive endovascular treatments for venous disease and complex aortic dissection and thoracic aneurysm repair. Fellowship Program Director.
Chief Medical Officer
Graybug Vision, Inc.
Redwood City, CA
Graybug is a clinical-stage biopharmaceutical company focused on developing transformative medicines for the treatment of diseases of the retina and optic nerve.
Chief Medical Officer
ForSight VISION5 (now Allergan)
Menlo Park
(Acquired by Allergan for $95M plus milestones) Sustained-delivery of bimatoprost using a novel ocular insert for the treatment of glaucoma/ocular hypertension. Phase 1, 2 development programs and Phase 3 planning. Development of fixed combination (bimatoprost/timolol) ocular insert for glaucoma/ocular hypertension.
Vice President - Clinical Medicine (Ophthalmology)
Shire
Brisbane, CA
Global clinical development lead for Xiidra (lifitegrast ophthalmic solution) for dry eye disease (acquired from SARcode Bioscience). Approved by FDA July 2016.
Chief Medical Officer
SARcode Bioscience Inc.
Brisbane, CA
(Acquired by Shire for $160M plus future milestones). Development of lifitegrast ophthalmic solution for dry eye disease. IND filing through NDA.
Senior Group Director - Division of Tissue Growth and Repair
Genentech
South San Francisco, CA
Clinical development team leader for ranibizumab (Lucentis), Phase 1b through BLA-filing and FDA approval (June 2006); neovascular age-related macular degeneration(AMD), diabetic macular edema (DME), retinal vein occlusion (RVO). Cardiovascular medicine - clinical lead sBLA TNKase (tenecteplase) approval - acute myocardial infarction, sBLA Activase approval (alteplase) - acute ischemic stroke, sBLA approval CathFlo Activase (alteplase) - restoration of function to central venous access devices.
Education
UC San Diego
Diagnostic Radiology
Chief Resident
University of Minnesota Medical School
J. Thomas Livermore Award - Hematologic Research American Heart Association - Research Award National Heart, Lung, and Blood Institute - Research Award
Carleton College
Chemistry
Charles Semba (仙波), MD's Contact Information
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