Carl Tilbury

* Project goal: determine if furnace instrumentation is sufficient for safe operation * Result: Recommended no action required regarding instrumentation gaps on 3 older furnaces * Performed quantitative risk analysis for 3 older furnaces with instrumentation gaps compared to current standards * Determined risk reduction potential of fixing gaps and prioritized those with greatest impact * Concluded no upgrades achieved sufficient reduction within established risk framework to justify their expense

* Led team to redesign industrial software * Software predicts crystal growth shapes and enables industrial crystallization engineering * Designed new algorithms to execute recent research (models developed during PhD) * Developments greatly extend applicability of software to industrial examples * Managed 2 post-doctoral scholars and hired 1 undergraduate computer engineer * Re-coded software in object-oriented fashion (order 10,000 lines) * Presented upgrades to pharmaceutical company sponsors * Advised team on future strategy for continued software development and industrial adoption

* Project goal: develop model to predict hydrate formation for complex drug compounds * Result: produced model that is now implemented in R&D workflow to reduce costs for molecular drug pipeline * Model mitigates costly risk of undiscovered solid forms (quantitative analysis enables targeted experiments) * Learned and optimized implementation of quantum chemistry software (COSMOlogic) to predict solution thermodynamics, then concluded method to be insufficient for hydrate prediction * Developed new approach with increased predictive power by combining COSMO-generated conformations with data-driven tools (CCDC hydrogen-bond-propensity analysis) * Prepared external publication post-internship (first author, in press) to disseminate technique, enabling risk reduction through computational drug design

Activities and Societies: MIT Men's Lacrosse Team

Research: Developing methods to reduce phosphorus content of algal biodiesel * Identified algae growth as the primary target, to achieve phosphorus reduction economically * Due to limited success at tailoring growth conditions, evaluated and proposed the most-promising removal options Design Project: Post-combustion carbon capture plant (team of 6) Personal responsibilities: * Designed and costed reactive absorption column * Optimized solvent flow by connecting absorber & stripper simulations * Designed plant-wide control & instrumentation system Activities and Societies: Cambridge Men's Lacrosse Team 2009, 2011-2012 (Vice-Captain 2011, Captain 2012)

Research Scope: Enhancing mechanistic models of crystal growth by improving both their accuracy and general applicability Advisor: Michael Doherty * Created MATLAB codes to implement these models, which predict the crystal shape under specified growth conditions * Developed a model that accounts for multiple mechanisms, to capture the effect of supersaturation * Introduced a more accurate framework for modeling solvent effects and collaborated with DuPont to test predictions * Mentored post-doctoral student in development of industrially funded crystal shape prediction program (ongoing project) * 3 Publications printed, 1 Publication accepted * Presented research nationally and internationally at 4 conferences * Experience with CCDC Mercury software and crystallography Activities and Societies: UCSB Men's Lacrosse Team 2013-2015 (Captain 2015)