雁滨 管

♦ 迅速组建Biacore、FACS和Q-TOF生物分析平台；建立化验方法和实验SOP；招募组员，领导队伍 ♦ 共约40个研发项目得到Biacore系统的大力支持，其应用广泛且至关重要：受体-配体结合、小分子亲和力、抗体筛选和表征、人源化、热点突变、亲和力成熟、种属交叉反应、结合特异性、Fc工程改造和抗原表位定位等 ♦ 准备相关部分的PCC、专利申请和FDA/CFDA IND申报资料；多次代表公司出席并一次通过CFDA现场核查 ♦ 与部门内外通力合作，群策群力，保质保量、及时准确地完成项目 Biophysical Chemistry Group Leader, Biomedicine Department, Shanghai Hengrui Pharmaceuticals Co., Ltd, Shanghai ♦ Built up Biacore, FACS, and Q-TOF bioanalytical platforms; established assay protocols and laboratory SOPs; recruited members and led the team ♦ Utilized Biacore system to support ~ 40 drug discovery projects in a variety of applications, including receptor-ligand binding assay, small molecule affinity, antibody screening and selection, humanization, hot-spot mutation, affinity maturation, species cross-reactivity, specificity, Fc engineering, and epitope mapping ♦ Prepared PCCs, patents, and FDA/CFDA IND packages, and represented the company at CFDA on-site reviews ♦ Collaborated closely with intra- and inter-departmental function groups to deliver projects in time

♦ 专职Biacore技术，在化验方法开发及验证、结构功能研究和质量保证等领域，对生物分子相互作用进行准确、高效和灵活机动的无标记实时分析；负责仪器检修和日常维护 ♦ 丰富的实际操作经验，从分子固定化（共价偶联或捕获）、再生条件摸索、上机编程、系统运行、正确选模及图形拟合到结果解释，贯穿始终 ♦ 擅于在结合物筛选和排序、亲和力测定和动力学分析过程中，及时发现并解决各种技术难题（如：低分子量、低纯度、亲合作用、溶剂效应、物质迁移、非特异性结合、基线漂移等） ♦ 提供数百份高质量数据，同时博得来自公司内部及大客户辉瑞的高度好评 Bioanalytical Scientist, Pfizer-CrownBio Department, Crown Bioscience Inc., Taicang 2010-2012 ♦ Specialized in Biacore technology to perform label-free analysis of biomolecular interactions in real time with high sensitivity, efficiency and flexibility in assay development and validation, structure-function studies, and quality control; performed routine instrument maintenance ♦ Immense hands-on experience all the way from covalent coupling/capture-based immobilization, regeneration scouting, programming, on-line system running, model selection and curve fitting, to result interpretation ♦ Proficient in targeting and solving technical problems (such as low molecular weight, low purity, avidity, bulk effect, mass transfer, non-specific binding, and drifting baseline) in binder screening and ranking, affinity determination, and kinetic analysis ♦ Provided hundreds of high quality data, and achieved company-wide recognition and client satisfaction from Pfizer, Inc.

♦ 学位论文：细胞－微结构表面相互作用：植入式生物传感器防生物污染的新前景 ♦ 2008－2010年，美国生物工程学会（IBE）会员 Ph.D., Biological Engineering, University of Georgia, U.S. 2004-2009 ♦ Dissertation: Cell-Microstructured Surface Interactions: Promise for Anti-biofouling Activity in Implantable Biosensors ♦ Member of Institute of Biological Engineering (IBE), 2008-2010

B.S., Pharmaceutical Engineering, Tianjin University