毛伟峰 毛

Project Operation and Management  Responsible for all existing pre-clinical projects' in vitro biological testing, pharmacological efficacy testing, and coordination of ADME and PK-related assays. Set measurable and achievable goals and timelines for each assigned project; regularly update project progress.  Conduct quarterly discussions on significant issues and their solutions for the ongoing projects, consulting with domestic and international experts in the fields of pharmacokinetics, toxicology, and clinical advisory.  Submit 1-2 new target proposals quarterly and actively participate in discussions, questions, and suggestions from colleagues. Develop a detailed POC (Proof of Concept) work plan for approved reports and targets.  Establish collaboration agreements with major CRO companies; evaluate and profile potential CRO partners, understanding their capabilities, pricing structures, strengths, and weaknesses, with quarterly updates. External Collaboration  Maintain regular communication and project updates with strategic partners such as Exscientia and Boundless.  Conduct periodic communication and meetings with investors and collaborators, addressing inquiries and adjusting future plans as needed.  Maintain close collaboration with domestic hospitals, providing regular updates on the transformation and clinical progress of projects like PRMT5. Notable Contributions  CDK7 project approved for Phase I clinical research in Belgium, EU in April 2023.  PRMT5 project internally nominated for PCC in June 2023, planning for mid-2024 application for clinical trials in China and the United States. Biology Department Team Building, Platform Development, and Operational Management  Currently leading a team of approximately 5 people, with plans to expand to around 10 members in 2-3 years.

Project handling & CRO collaboration  Manage and oversee the progress of small molecule and ADC projects  Set up measurable / attainable goals and timelines for each project  Conduct due diligence and provide advice from technical perspective to support license-in programs  Sign CDA, MSA, & WO with major CRO companies and evaluate other CROs for future collaborations  Draw a technology map collaborated CROs to understand their capabilities, pricing, advantages, and disadvantages and update quarterly Internal capability build-up  Lab design & equipment order, make preparations for new facility running properly  Recruit bench scientists for future in-Vitro POC assays  Work with CMC colleagues together to get the appropriate strategy and team build-up New target proposal  Propose at least 1-2 new targets each quarter  Make suggestion for other proposed targets  Make detailed plan of POC assays for approved proposal

Project evaluation and development  Search the new targets in clinical trials of phase 1 or phase 2 and make arrangements of internal fast evaluation with some interested ones  Proof of concept of those targets with internal experimental evidences, not limited to in-Vitro or in-Vivo data; Set up a series of in-Vitro screening assays  Transfer the POC projects / targets to immunology / oncology team for routine screening  Act as project leader / of some projects to make sure everything OK until IND filing  Make proposal how to improve enterprise pipelines occasionally Exploration for new technologies Platform setup and training course  A key member of training course committee, responsible for the training course of whole in-Vitro team, not limited to exploration team (4 persons), but also oncology, immunology and translational in-Vitro team (20-25 persons), including both knowledge and operation parts  Set up several screening platform in biophisics and high content screeening, such as ITC, BIAcore and Operatta  Take over and optimize the previous platform (mini KP, hERG biding, oncology cell panel, healthy cells screening), and expand the new targets, including epigenetics, proteases, phosphatases to make a comprehensive understanding of target selectivity

Collaboration with clients  Involved in international and domestic collaborations with top pharmaceutical companies, biotech companies or research institutes  Experienced in-Vitro assays, including target validation, high throughput screening, lead optimization, PCC & IND; projects involves the oncology, immunology, inflammation and anti-bacteria area  Familiar with in-Vitro assays for the related work and be capable to deliver in a short time Achievements  Internal collaboration with top pharmaceutical companies to validate the target, and set up a series of compound profiling assay criteria; 10+ projects with milestone in the PCC nomination and further progress  Integrated service and collaboration with domestic companies for me-too or me-better drugs. Over 30 projects have been nominated PCC and approved of IND application by CFDA. Responsible for cell panel screening and finish the compound profiling with 400+ cancer cell lines in 2 months Platform set up  Take the lead role to set up the kinase panel service and 120+ protein kinases available  Responsible to setup assays for epigenetic targets, including demethylases, methyl transferases, Bromo domain, deacetylases, acetyltransferases, and 50+ targets available for the internal / external client service  Involved in the cancer cells identification, assay development / validation, and 400+ cell lines available for cell proliferation assays, cyto-toxicity, cell cycle, apoptosis and other applications  Help the in-Vitro team to set up the safety panel, including GPCR, protein kinases, PDE, transport & ion channels and 50+ binding assays or functional assays available Team building  20+ team members for multiple programs  Provide the essential professional and operation training courses for all the team members and on-site English training, joint master degree training for key members  Retain the key members and below average turnover rate in WuXi biology  Regular team building activities

 Responsible for the regular sales and marketing work for all products  Communication with vendors, including the business forecast, yearly revenue demands, technical questions, marketing activity plans & schedules and reports  Help GM to deal with some big cases  Find new collaborations with potential vendors to replenish and expand the product portfolios  Responsible for instrument installation, calibration & validation, and client training course