Xuejun Zhang

CSO/Head of HumanWell Innovative Drug R & D Institute

About

Seasoned medicinal chemist with project leader/managerial experience and proven track record in the discovery of small molecule drug candidates across multiple disease areas(oncology, immunology, metabolic disease, obesity and cardiovascular disease), and broad knowledge of disease biology in related therapeutic areas Project leader and key inventor of SHR0302(a selective JAK1 inhibitor for rheumatoid arthritis, now in Phase III clinical trial at China and multi Phase II clinical trials in other countries) Extensive experience with structure based and fragment based drug design; proficient at designing and synthesizing new molecules to solve critical issues related to affinity, selectivity, physicochemical property, ADME, tissue distribution, in vivo pharmacology and toxicology Extensive experience with external collaboration and CRO management. Master of modern synthetic methods and new technologies

Country

China

City

Wuhan

Industry

Pharmaceuticals

Skill

Organic Chemistry, Drug Design, Medicinal Chemistry, ADME, Organic Synthesis, Drug Discovery, Biotechnology, Laboratory, Synthetic Organic Chemistry, Chemistry, Pharmaceutical Industry, Life Sciences, Biochemistry

Experience

CSO/Head of HumanWell Innovative Drug R & D Institute

Humanwell Healthcare (Group) Co., Ltd（人福医药集团）

2018-1 - Present · 8 yrs 9 mos

Wuhan, Hubei, China

Principal Scientsit II

Eli Lilly and Company

2012-3 - 2017-12 · 5 yrs 10 mos

Shanghai

Group Leader of Medicinal Chemistry

Hengrui Pharma

2009-6 - 2012-3 · 2 yrs 10 mos

Research Associate

Scripps Research

2007-6 - 2009-6 · 2 yrs 1 mo

Research on Chemical Etiology of Nucleic Acid Structure with Professor Albert Eschenmoser Representive Publications: "Mapping the Landscape of Potenially Primordial Informational Oligomers: Oligodipeptides Tagged with Orotic Acid Derivatives as Recognition Elements" Zhang, X.; Krishnamurthy, R.(Work done in Professor Albert Eschenmoser Lab) Angew. Chem. Int. Ed. 2009, 48, 8124-8128. http://www3.interscience.wiley.com/journal/122602870/abstract Abstract:Partner up! Base-pairing properties of oligo-dipeptides tagged with orotic acid and its 2,4-diamino counterpart (see structure) are found to be consistent with previously observed correlations between pKa values and the pairing strength of complementary bases. The combined results provide a general justification for anticipating the base-pairing propensity of a recognition element based on its pKa value and the pH of the medium.

Education

University of Wisconsin-Madison

Organic Chemistry

2006 - 2007 · 1 yr

Representive Publications: 1. "Synthesis of Chiral alpha-Amino-beta-Lactams via a Highly Stereoselective Kinugasa Reaction of Ynamides." Zhang, X.; Hsung, R. P. Li, H.; Zhang, Y.; Johnson, W. L.; Figueroa, R. Org. Lett. 2008, 10, 3477-3479. (Highlighted by Synfacts, 2008, 1056). 2. "A Triazole-Templated Ring-Closing Metathesis for Constructing Novel Fused and Bridged Triazoles." Zhang, X.; Hsung, R. P. Li, H. Chem. Commun. 2007, 2420-2422. 3. "Cu(I)-Catalyzed Azide-[3 + 2] Cycloadditions of Ynamides and Bis-Ynamides." Zhang, X.; Li, H.; You, L.; Tang, Y.; Hsung, R. P. Adv. Synth. Catal. 2006, 348, 2437-2442. 4. "Tandem Azidination- and Hydroazidination-Huisgen [3 + 2] Cycloadditions of Ynamides. Syntheses of Chiral Amide Substituted Triazoles." Zhang, X.; Hsung, R. P.; You, L. Organic Biomol. Chem. 2006, 4, 2679-2682. (Featured on the Front Cover).

University of Minnesota

Organic Chemistry

2002 - 2006 · 4 yrs

Representive Publications: 1. "Copper(II)-Catalyzed Amidation of Alkynyl Bromides as a General Synthesis of Ynamides and Z-Enamides. An Intramolecular Amidation for the Synthesis of Macrocyclic Ynamides." Zhang, X.; Zhang, Y.; Huang, J.; Hsung, R. P.; Kurtz, K. C. M.; Oppenheimer, J.; Petersen, M. E.; Sagamanova, I. K.; Tracey, M. R. J. Org. Chem. 2006. 71, 4170-4177. 2. "Organic Synthesis Using of 1-Acetoxy-1,3-butadiene." Zhang, X.; Hsung, R. P. Encyclopedia of Reagents for Organic Synthesis. 3. "Syntheses of 2-Pyrones via Electrophilic Substitutions at C7 of 6-Methyl-4-Hydroxy-2-Pyrone Through Mono- or Dianion Formation." Zhang, X.; Munoz R. L. P.; Hsung, R. P; et al Synthesis. 2007. 749-753. 4. "Brønsted Acid-Catalyzed Highly Stereoselective Arene-Ynamide Cyclizations. A Novel Keteniminium Pictet-Spengler Cyclization in Total Syntheses of (±)-Desbromoarborescidines A and C." Zhang, Y; Hsung, R. P.; Zhang, X.;et al Organic Lett. 2005, 7, 1047-1050.