Yun (Ivy) Wei

Senior Scientist @ AstraZeneca

About

I’m a seasoned immunologist in skin disease drug discovery, motivated by a simple purpose: translate complex biology into real relief for patients. I’ve driven translational packages that advanced biologics through pre-IND, contributed to solid tumor/skin disease programs, and helped shape biomarker strategies that link mechanism to measurable clinical learning. I bring curiosity, rigor, and humility—and a strongly team-first mindset—I believe the fastest path to better medicines is building it together.

Country

United States

City

Gaithersburg

Industry

Pharmaceuticals

Skill

Biology lead, Molecular, Target discovery, Spectral flow cytometry, Subteam management, Regulatory writing, Target engagement assay, Ex vivo and In vitro modeling, Precision discovery, Translational Research, Biomarker identification, Strategic Thinking, Molecular Biology, Assay Development, Drug Discovery, Protein Expression, Cell, Molecular Cloning, Biotechnology, Immunology

Experience

Senior Scientist

AstraZeneca

2024-11 - Present · 1 yr 11 mos

Gaithersburg, Maryland, United States

Lead therapeutics development to tackle skin diseases.

Senior Scientist, Program translational research lead

Bristol Myers Squibb

2023-6 - 2024-6 · 1 yr 1 mo

Redwood City, California, United States

• Translational research lead for programs targeting tumor microenvironment (TME). Develop early translational research plan and manage translational sub-team activities to ensure program deliverables for preclinical milestones and to guide/inform clinical translational strategy. • Collaborate with biology and bioinformatics groups for strategic planning and execution on precision medicine approaches. • Oversee and execute on translational research plan focusing on proof of mechanism of action (MOA), target characteristics, patient indication prioritization, and predictive and pharmacodynamics (PD) biomarkers identification/refinement through close collaboration with technology (NGS, IHC and flow cytometry) and bioinformatics teams. • Drive above-asset translational efforts including development of biomarkers predictive of TME characteristics, and in vitro multi-cell type culture platforms.

Scientist

Bristol Myers Squibb

2021-4 - 2023-5 · 2 yrs 2 mos

Redwood City, California, United States

• Executed translational research plans to support multiple programs targeting TME with focus on receptor characteristics, indication prioritization, predictive and PD biomarkers identification/refinement, and target engagement assays. • Collaborated with biology and clinical biomarker teams to address translational questions that guide/inform clinical biomarker plan for TME targets in preclinical development • SME for human ex vivo platforms (peripheral, dissociated tumor or explant culture) to support programs and novel technology development. • Authored study reports for predictive biomarker and receptor characterization for multiple programs • Presented research findings at various BMS science forums for program and above-asset efforts • Co-led translational research sub-team • Managed translational research department meetings by driving the agenda and identifying speaker • Oversaw laboratory instruments and coordinated sourcing of human tissue specimen with multiple vendors. • Managed and developed a summer intern.

Associate Scientist

Amgen

2015-12 - 2021-4 · 5 yrs 5 mos

South San Francisco

Discovery research in inflammatory diseases and Immuno-oncology.

Staff Research Associate

University of California, San Francisco

2014-9 - 2015-12 · 1 yr 4 mos

San Francisco

Molecular capacity expansion for Herbert Lab; Mechanistic study on Trefoil factor 3 (TFF3) signaling (see publications)

Scientist II

BioDuro

2011-4 - 2014-1 · 2 yrs 10 mos

Beijing City, China

Antibody and protein drug development to customers in US; Broad project experiences in antibody humanization and affinity maturation, therapeutic protein engineering, new antibody format development, etc