Yu Lu

Department Head of API Process R&D organization at WuXi STA with 400-500 team members

Department Head of API Process R&D organization at WuXi STA with 100-150 team members

Prolific experiences in regulatory submissions (IND/IMPD/NDA) of small molecules and synthetic peptides; Strategic oversight of Process R&D and GMP production of DS candidates for clinical trials; Extensive collaboration with CDMOs in the US/EU/Asia; Effective communication within broader CMC team and portfolio team at corporate level.

Process chemistry project lead and team leader for pre-clinical and clinical drug candidates including small molecule APIs and peptide APIs

API process design and development with a focus on continuous flow chemistry

• Responsible for the discovery of broad-spectrum fungicide Adavelt through rational SAR design • Took ownership in research area and coordinated project team in exemplification of chemistry • Collaborated with process chemists to transfer and modify route for field sample preparation (>100 g) • Communicated effectively within multidisciplinary team to ensure timely delivery of research values • Solved organic synthesis problems for other projects in discovery chemistry through internal requests

Thesis title: “Carbon-Carbon Bond Formation via Catalytic Hydrogenation and Transfer Hydrogenation: Application in the Total Synthesis of Bryostatin 7” • Initiated and accomplished the most concise total synthesis of bryostatin (20 longest linear steps) • Proposed and synthesized biologically functional analogues of natural products • Critically analyzed research outcomes and strategically tackled problems in route optimization • Improved synthetic efficiency by incorporating novel catalytic C-C bond forming methodologies • Developed asymmetric bis-allylation on unprotected diols to rapidly construct polyols • Collaborated with colleagues in multiple projects in leading or supporting role • Simultaneously worked on 3 projects and timely delivered published results • Mentored undergraduate and junior graduate students in their lab practices • Supervised undergraduate organic chemistry laboratories as graduate teaching assistant

• M.S. Thesis: “Ligands for the Sigma Receptor and the μ-Opioid Receptor” • Synthesized functionalized piperidine and piperazine analogs, conducted sigma receptor binding assay, and analyzed structure-activity relationship • Investigated chemo-selective mono-iodination of Dmt (2’,6’-dimethyl-L-tyrosine) and prepared iodinated peptides by solid phase synthesis • Delivered weekly one-hour lecture covering theoretical and experimental organic chemistry, and led two-hour undergraduate organic chemistry laboratories

Total Synthesis of Natural Product Design and Synthesis of Natural Product Functional Analogs Transition Metal Cataylzed C-C Bond Forming Hydrogenations

Undergraduate Research Project: Towards the Total Synthesis of Coenzyme Q10