Yogesh Chutake
Director, Translational Medicine @ Accent Therapeutics, Inc.
About
I am a translational medicine leader with 12+ years of expertise in oncology and neurodegenerative diseases, bridging preclinical discovery to early-phase clinical trials. Known for strategic leadership in disease biology, biomarker strategy, and assay development, I excel at driving innovative drug discovery programs targeting solid tumors, myeloid malignancies, and rare genetic diseases. As Associate Director of Translational Medicine at Kymera Therapeutics, I spearheaded the KT-253 program—a novel MDM2 degrader in Phase 1 trials—by developing biomarker strategies for proof of mechanism and biology, leading cross-functional collaborations, and managing clinical sample analysis through central labs and CRO partnerships. With a proven track record in strategic project leadership, I have successfully advanced early-stage programs to regulatory filings and clinical trials while building high-impact collaborations with key opinion leaders, academic institutions, and industry stakeholders. As a dedicated mentor, I have recruited and developed talented teams, empowering them to deliver transformative results. I thrive at the intersection of science and strategy, leveraging my expertise to unlock the full potential of translational medicine and deliver therapies that make a meaningful difference in patients' lives.
United States
Boston
Biotechnology
Translational Medicine, Neuroscience, Biomarkers, Drug Development, Epigenetics, Molecular Biology, CRISPR-Cas9, Triplet Repeat Diseases, Next-Gen Sequencing, ChIP, Bioprocessing, Downstream Processing, Basic Biochemistry & Molecular Biology techniques, Molecular Genetics, RNA Immunoprecipitation, Cell Culture, Western Blotting, NOMe-Seq, Molecular Cloning, Polymerase Chain Reaction (PCR)
Experience

Independent Consultant, Translational Medicine
Greater Boston
Translational development in Oncology and Neuroscience disease area.

Scientist
Syros Pharmaceuticals
Cambridge, Massachusetts

Research Scientist
Oklahoma City, Oklahoma Area
• Extensive collaborative translational research with Biopharmaceutical industry and academic research institutes on class I HDAC inhibitors, as a therapeutic modality in neurodegenerative disease • Experience in handling primary cells, blood and tissue samples from human and humanized mouse models, and subsequent biomolecule extractions • CRISPR/Cas9 genome editing • Next-Gen sequencing, Illumina platform: Library prep to Bioinformatics analysis - high-throughput targeted bisulfite sequencing, NOMe-seq, RNA-seq • Excellent analytical, communications & interpersonal skills, with eight high impact publications • Invited talks and awards by the American Society of Human Genetics, National Ataxia Foundation, Friedreich Ataxia Research Alliance, University of Pennsylvania and Oklahoma Center for Neuroscience

Graduate Teaching Assistant
Monroe, Louisiana Area
- Taught Pharmacy Care to final year PharmD students - Trained students on professional Patient Counseling techniques - Demonstrated proper use of medication devices - Supervised and graded compounding and dispensing practices
Yogesh Chutake's Contact Information
Phone
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