Yizhen Xu

Chief Medical Officer

About

• Physician-scientist and biotech executive with 20+ years of experience leading translational and early to late stage clinical development in endocrine, metabolic (diabetes, obesity and MASH), cardiovascular, kidney, and rare diseases (CNS, metabolic, neuromuscular), oncology and immunology with extensive experience in biologics (GLP-1) and gene therapy (AAV and RNA), deep understanding of unmet medical needs, strong business acumen and excellent leadership. • Passionate about building efficient, compliant, and patient-focused clinical programs across the U.S., Europe, and Asia. • Currently exploring advisory and leadership opportunities in innovative biotech and emerging therapeutic platforms.

Country

United States

City

Princeton

Industry

Biotechnology

Skill

CMO management, Medical Group Management, Business Development, Pharmaceutical Industry, Clinical Trials, GCP, Diabetes, Clinical Development, Biotechnology, ICH-GCP, Drug Development, EDC, Clinical Monitoring, Endocrinology, Cross-functional Team Leadership, Internal Medicine, Medicine, Clinical Research, Medical Affairs, Good Clinical Practice (GCP)

Experience

Chief Medical Officer

RiboX Therapeutics

2024-1 - 2025-9 · 1 yr 9 mos

New Jersey, United States

Key accomplishments: Built high-performing CMR team, developed and implemented clinical and regulatory strategies. Led the cross-functional teams to advance the preclinical assets to clinical stage and achieved historical milestone by becoming the world's first company to dose circular RNA.

Vice President Clinical Development

AskBio Inc.

2021-3 - 2024-1 · 2 yrs 11 mos

Research Triangle Park, NC

Key accomplishments: Built and led the Clinical Development team to support all clinical and early pipeline programs, including CNS, neuromuscular, metabolic, CHF, hematology diseases. Provide clinical input in corporate strategic discussion and decision, including pipeline candidates’ determination and BD activities.

Medical Director, Clinical development and outcome research

Novo Nordisk

2006-7 - 2021-3 · 14 yrs 9 mos

Princeton, New Jersey, United States

2006-2008 & 2011-2021 Associate Medical Director/Medical Director of Clinical Development, CVOT program Lead and NASH program Lead. 2010-2011 Medical Director, Medical Affairs. 2008-2010 Clinical Director, Victoza Commercialization team, Strategic Business Development. Key accomplishments: Developed global clinical development strategy, provided medical oversight to GLP-1 clinical trials (Phase 1 to phase 4), including diabetes, obesity, CVD and MASH indications, to ensure successful trial design, execution and reporting. Participated in GLP-1 commercialization team to support blockbuster launch. Developed and implemented medical strategy and life cycle management strategy for GLP-1 products.