Yixiao Li, Ph.D.

Organic Chemist | API Process Development | Reaction Optimization Ph.D. in Organic Chemistry with extensive experience in multi-step synthesis, reaction optimization, structure-property relationships (SPR), and structure-activity relationships (SAR). My research focuses on developing scalable and efficient synthetic methodologies, particularly in API synthesis and pharmaceutical applications. Key Expertise: Multi-step synthetic organic chemistry – Designed novel synthetic pathways, leading to the successful synthesis of 50+ guanidines. Process development & optimization – Improved synthetic efficiency, reducing reaction steps from 9 to 4 and increasing yields by 7×. Computational chemistry (DFT modeling) – Applied Gaussian simulations to predict reaction mechanisms and improve selectivity. Analytical techniques – Proficient in NMR (1D/2D), LC-MS, IR, HPLC, and automated chromatography for compound characterization. Regulatory compliance – Knowledge of GMP/GLP standards, ensuring documentation integrity and process validation. I am passionate about translating scientific discoveries into industry applications, optimizing reaction conditions, and contributing to pharmaceutical and chemical innovation. Currently seeking opportunities in process chemistry, API development, and medicinal chemistry. Let's connect! Always open to networking, collaborations, and new career opportunities in the biotech, pharma, CRO and CDMO industries.