Yiren (Joy) Xu
Vice President @ WuXi Biologics
About
Experienced biochemist and biophysist with in-depth knowledge and skills in analytical chemistry. Focused on antibody characterization using a combination of technologies in analytical chemistry, structural biology and molecular biology. Specialties: Specialized in antibody characterization (Analytical Chemistry), protein-protein interaction (Biophysical techniques), molecular biology and protein purification. Highly self-motivated team player and independent researcher with excellent communication skills, problem solving ability , creativity and with demonstrated multi-task capability. Excellent collaboration experience with cross-functional groups.
China
Shanghai
Pharmaceuticals
HPLC, Biomolecular NMR spectroscopy, Isothermal Titration Calorimetry, Protein labeling, expression and purification, Molecular Cloning, Biochemistry, Protein Chemistry, Biotechnology, NMR, Lifesciences, Molecular Biology, Mass Spectrometry, Protein Expression, Antibodies, Protein Purification
Experience
Vice President
WuXi Biologics
Executive Director
WuXi Biologics
Shanghai, China
Senior Director
WuXi Biologics
Shanghai, China
Director of Analytical Sciences
WuXi Biologics
Shanghai City, China
Senior Scientist
Sutro Biopharma, Inc.
Responsible for expression optimization and scaffold screening for bispecific antibodies (BsAb) and antibody drug conjugates (ADCs). Analytical assay development for antibody characterization.
Scientist
Sutro Biopharma, Inc.
Responsible for expression optimization and scaffold screening for bispecific antibodies (BsAb) and antibody drug conjugates (ADCs). Analytical assay development for antibody characterization.
Post-doc
Genentech
South San Francisco, CA
Study the structure-dynamics-function relationship in monoclonal antibodies (mAb) exhibiting unpaired Cysteines-related heterogeneity. Improve the knowledge of mechanism of unpaired Cysteines formation in mAb production. 1. Conduct frontier researches to understand the root cause and impact of free-thiol related heterogeneity in mAbs. 2. Fab characterizations using structural biology (X-ray crystallography), analytical chemistry methods (HPLC and Mass Spectroscopy) and molecular biology. 3. Analytical and preparative method development and optimization (HPLC such as Agilent and FPLC such as AKTA). 4. Provide unique knowledge and skill set of structural biology and molecular biology to help development projects involving mAb chemical degradation and unusual CE-SES behavior. 5. Serve in postdoc committee to build a close postdoc community.
Ph.D student
The Ohio State University
Columbus, OH
Performed state-of-art NMR spectroscopy, and determined a high-resolution solution structure of a protein-protein complex. Designed and conducted a thorough characterization on protein-protein binding thermodynamics. 1. Implementation of novel NMR spectroscopy methods, and development of structure determination strategy of protein-protein complex. 2. Design and development of a complete characterization strategy of protein-protein interaction thermodynamics. 3. Method development and optimization of protein expression, isotope-labeling and purification. 4. Design protein constructs for structural and functional studies. 5. Supervision of undergraduate students' researches. In charge of training of NMR data acquisition and analyses.
Undergraduate Research Assistant
Fudan University
Shanghai, China
Cloning of the human RNA-binding protein into different vectors, and expression and purification of the recombinant protein from E. coli.
Education
University of California, Berkeley
Project Management
Courses: Project Management Quality Management Project Risk Management Project Planning and Control Project Procurement Management Human Factor and Team Dynamics in Project Management
The Ohio State University
Biochemistry
Fudan University
Biology
Yiren (Joy) Xu's Contact Information
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