Ying Xie

Principal Scientist @ Couragene

About

I'm an Associate Research Scientist working at Jiangbing lab at Yale school of medicine. I have over 10 years research experiences in various nucleic acids delivery (mRNA, Cas9/CRISPR, miRNA, siRNA, DNA, ASO). Skilled in pharmaceutical formulation and in vitro/in vivo product analysis. Now I'm working on mRNA dleivery and CRSPR/Cas9 delivery using novel polymer nanoparticles for clinical translational treatment of neurological and genetic disorders.

Country

United States

City

New York City Metropolitan Area

Industry

Higher Education

Skill

mRNA delivery, Nanomedicine, Gene Editing, Pharmaceutics, Cell Culture, Polymer, Chemistry, Formulation, Flow Cytometry, Confocal Microscopy, HPLC, Western Blotting, PCR, Cell Biology, ELISA, Nanotechnology, Adobe Photoshop, Microfluidics, Drug Delivery, miRNA

Experience

Principal Scientist

Couragene

2022-5 - Present · 4 yrs 5 mos

Associate Research Scientist

Yale University

2022-3 - Present · 4 yrs 7 mos

New Haven County, Connecticut, United States

Postdoctoral Associate

Yale University

2019-2 - 2022-2 · 3 yrs 1 mo

Greater New York City Area

• Development of polymer nanoparticles for mRNA delivery. 1) optimization of clinical translational formulations with microfluidic device; 2) lung specific delivery of mRNA for cystic fibrosis; 3) mRNA vaccine for infectious disease. • Development of CRISPR/Cas9 delivery system. 1) Engineer Cas9/gRNA complexes for precise HDR genome editing for T cell therapy in brain cancer. 2) Development of nanoparticles for gene editing in central nervous system.

Graduate Research Assistant

University of Nebraska Medical Center

2014-8 - 2018-10 · 4 yrs 3 mos

Greater Omaha Area

• Nanomedicines for drug/small RNA combinations in metastatic cancer therapy. • Development of polymers for nucleic acids delivery. • Tumor biology, miRNA, cancer stem cells, pancreatic cancer, breast cancer.