Yige (Hugo) Luo

Temab‑A (ABBV‑400 Top1i ADC, GEA): ⠂ Led US/Japan real‑world clinico‑genomic analyses (Caris ConcertAI, NCCE); identified biomarker‑defined subpopulations; presented at ASCO GI; shaped CDx and combination strategy. ⠂ Designed MET prevalence/overlap/concordance analyses; conducted prognostic analysis via treatment‑specific multivariate modeling. ABBV‑706 (Top1i ADC, SCLC): ⠂ Led AACR‑accepted study integrating multimodal clinico‑genomic data; identified/validated molecular subtypes; profiled tumor‑intrinsic and immune microenvironment correlates with survival; contributed epidemiology and target antigen data for ASCO abstract. Multispecific T‑Cell Engagers (TCEs): ⠂ Directed RWD biomarker landscape analyses; evaluated/validated antigen targets; investigated SoC impact, tissue‑specific expression, resistance mechanisms; delivered subtyping/pathway insights supporting clinical plans and asset positioning. CAR‑T Programs (ABBV‑461): ⠂ Built target nomination/risk assessment framework integrating multi‑omics data (TCGA, GTEx, BluePrint, Aster, Caris); optimized antigens for tumor specificity; incorporated microenvironment and prior therapy context into patient selection; partnered externally to align bioinformatics deliverables with IND packages. Novel Payload ADCs (ABBV‑319 GRM‑ADC): ⠂ Led GRM MoA and ADCC validation using Ph1 trial data; developed predictive PD biomarkers across models; characterized pediatric tumor antigen profiles.

PhD Dissertation (Kopp Lab): The origin of sexual dimorphism – from a perspective of fruit fly pheromones ⠂ Invented low-cost experimental method on insect pheromone extraction, increasing the scalability of phenotypic sampling by 10-fold while maintaining high reliability (90% average quantification accuracy calibrated by traditional methods). ⠂ Initiated and established the first D. prolongata (~200Mb genome size) genomic research panel (~200G sequencing data across 42 populations) and comparative transcriptomic research panel (~80G data), enabling large-scale hypotheses generation. ⠂ Performed variant analysis and genome-wide association analysis (GWAS) on quantitative traits using ~14M markers (SNPs and short indels). Discovered ~50 candidate genes by statistical inference and biological interpretation. ⠂ Conducted differential gene expression and GO enrichment analysis on tissue-specific RNA-seq data. Revealed 1 potential root cause (among ~50 DEG candidate genes) explaining trait divergence. Designed follow-up experiments for hypothesis validation. ⠂ Conceived and translated project ideas into award-winning ($2K) research proposal. Collaborated with interdisciplinary professionals worldwide. Presented investigation results at select conferences. Published paper in highly regarded journal.

⠂ Taught 16 in-person and remote lab classes of ~30 undergraduates, imparting biological concepts and solutions to study questions. Received 90% teaching effectiveness rating among students.

⠂ Taught 10 in-person discussion classes of ~30 undergraduates, imparting concepts in genetics and solutions to study questions. Received 90% teaching effectiveness rating among students. ⠂ Developed, proofread and benchmarked 30+ test questions approved by 3 professors to be deployed during course examinations.

⠂ Applied state-of-art ML algorithms to identify pathogenic mRNA splicing variants in ~100 colorectal cancer patients, providing scalable solutions (~400G data analyzed in 6 hours) to lead generation of disease biomarkers. ⠂ Deployed automated bioinformatics workflow of NGS-based variant discovery, partnering with 6 cross-functional stakeholders in 2 therapeutic areas for druggable candidate mining & validation. ⠂ Presented project findings in diverse setups, including general audience covering 3 functional domains beyond R&D and 20+ computational biology experts. Received 10+ peer commendations.

⠂ Maintained and exported 2 strains of Drosophila prolongata to Research Lab at California. ⠂ Assisted in analyzing courtship songs from behavior assay recordings of Drosophila serrata. ⠂ Presented use case applications of quantitative genetics methods on female mate choice research before 10 seminar attendees, incl. 2 professors.

⠂ Characterized chemical identities and quantified abundance of fruit fly pheromones using Gas Chromatography - Mass Spectrometry (GC-MS). Tested research hypotheses on correlations between pheromone profiles, female fecundity and male fighting success.

⠂ Tested and confirmed research hypothesis on sexual dimorphic composition of cuticular hydrocarbons in Drosophila prolongata via GC-MS analysis. ⠂ Presented 15min talk at research symposium before 40+ attendees incl. 3 professors and 2 teaching assistants, winning committee-nominated award in research performance.

⠂ Led discussion of 12 undergraduates on literature ranging from classical Mendelian genetics to cutting-edge genomic editing techniques incl. CRISPR-CAS9. Polished student-made presentations on weekly discussion topics. ⠂ Presented one course preparation talk at instructor-TA pre-lecture meeting before 8 professors and 12 teaching assistants.

Research on Cold Resistant Peptide (CRP) Derived from Arctic Cods ⠂ Artificially engineered β-galactosidase with CRP tagged and expressed recombinant enzyme in E.coli. Purified CRP-tagged β-galactosidase by nickel affinity chromatography. Examined cold resistance by enzyme kinetic assays.

Kopp Lab, Department of Evolution and Ecology, Center for Population Biology

Course: Probability, Mathematical Statistics I & II, Linear Regression, Analysis of Variance and Causal Inference, Computational Statistics, Multivariate Analysis, Stat Data Technologies, Advanced Stat Computing, Time Series Analysis, Big Data Optimization, Statistical Machine Learning