Yao Chen

Principal Scientist, Lab lead @ Sanofi

About

Ph.D. Principle Scientist with demonstrated success working on multiple project teams. Over 18 years extensive biotechnology industry experience in multiplexing immunoassay development and validation utilizing bead-based Luminex xMap technology, MSD (Meso Scale Discovery) platform and automated Single Molecular Array (Simoa) technology, NULISA, Olink, Spear, SomaScan in a high-throughput industrial R&D setting. Quick and enthusiastic learner, dedicated to the generation of high-quality and timely results. Diverse background in molecular cloning, protein biochemistry and immuno-assays. Skilled in all areas of lab operations as well as designing and troubleshooting experiments. Good communication skills, strong analytical skills. Excellent record of productivity and performance. Medical background built from eight years practicing of medicine in a hospital setting.

Country

United States

City

Cambridge

Industry

Pharmaceuticals

Skill

Olink, NULISA, Sequencing, SomaScan, Spear, multiplex immunoassay development, validation and manufacturing transfer, expertising on both Luminex and MSD platform, ELISA, PCR, Protein expression and purification, cDNA library screening, DNA microarray, Western Blotting, Immunohistochemistry, Tissue array, Microsphere conjugation, Cell Culture, PCR primer design, DNA sequencing, Vector Cloning

Experience

Principal Scientist, Lab lead

Sanofi

2022-1 - Present · 4 yrs 9 mos

Cambridge, MA

Lead the immunoassay proteomics group responsible for the exploration, development, and implementation of advanced immunoassay technologies, including Meso Scale Discovery (MSD), Ella, Simoa, single-cell proteomics (IsoPlexis), Olink, NULISA, SPEAR, and SomaScan. Leverage these platforms to interrogate disease biology and drug mechanisms of action, enabling the discovery of novel biomarkers and the validation of human therapeutic targets. Partner closely with Computational Biology and multiple Therapeutic Area (TA) teams, with primary focus on Neurology and Immunology & Inflammation, to support drug development from preclinical through clinical stages. Deliver high-quality, purpose-built proteomics assays and analytical solutions that generate actionable biomarker insights

Principal Scientist

Quanterix

2012-10 - 2022-1 · 9 yrs 4 mos

113 Hartwell Ave, Lexington, MA

Lead multiple assay prototyping, development & optimization and assay validation. Responsible for tech-transferring documents (ie Protocol, Product Requirement Document, Manufacturing Procedure Master Files), SOP editing and reviewing, phase review presenting. Lead scientist and senior RA on assay troubleshooting, reagents and process optimization; provide guidance on good documentation practice, multiple project prioritizing and handling. Serve as a technical resource for the Marketing and Manufacturing departments, supporting product development, communication, and production processes.

Scientist

MESO SCALE DIAGNOSTICS, LLC.

2010-11 - 2012-9 · 1 yr 11 mos

1601 Research Boulevard Rockville, MD 20850

Manage assay development activities. Plan and conduct assays development, performing data analysis using MSD proprietary technique (MULTI-ARRAY technology). Provide critical review and trouble- shooting strategies on review board meeting. Detailed documentation preparation and technique transferring. Provide assistant and support to QC, QA, Marketing and tech support department. Supervise RAs (Research Associate) by providing technique or process guidance and analytical tutoring.

scientist II

Merck Life Science

2007-4 - 2010-11 · 3 yrs 8 mos

Develop and implement multiplex biomarker assays using Luminex xMAP technology, providing quality detection tools for research labs. Facilitating R&D product transfer to manufacturing by providing SOP, QC and manufacturing documents and troubleshooting problematic transfers. Providing R&D support to Marketing, technique support team.