Yali Li
Associate Director @ Johnson & Johnson Innovative Medicine
About
Antibody/protein discovery and development; CAR-T drug development; Expertise and skills in CAR-T/antibody/protein analysis and characterization assay development; Trained in biochemistry, analytical chemistry, immunology, molecular biology, and structural biology with broad technical expertise.
China
Shanghai
Biotechnology
Biacore Assay, Protein Purification and Characterization, ITC Assay, Octet Red System, Project Management, Protein Chemistry, Protein Purification, Assay Development, Biacore, Enzyme Assays, High Throughput Screening, Cell, Protein Expression, Purification, Antibodies, Biochemistry, Molecular Biology, Drug Discovery, Fluorescence, Microbiology
Experience
Associate Director
Johnson & Johnson Innovative Medicine
Pudong, Shanghai
Principle Scientist, Pharmaceutical Development and Manufacturing Sciences
Johnson & Johnson Innovative Medicine
Pudong, Shanghai, China
Work on drug development of CAR-T, Antibodies, Bi-specific antibodies
Associate Director, USP China
US Pharmacopeia
Shanghai
Associate Director, Biologics Department
ChemPartner
上海
Lead and build up large molecule analytical development team Study on antibody binding to antigen, FC receptors, C1q etc Publications: Yali Li et al Characterization of antibody-C1q interactions by Biolayer Interferometry (2018) Analytical Biochemistry 549:143-148.
Principle Research Scientist I, Biologics Department
ChemPartner
Shanghai City, China
Technical and project leader of analytical development projects. Developed therapeutic protein drug release/characterization methods.
Senior Scientist/Biacore Group Leader, Biologics Department
ChemPartner
Shanghai China
Built up SPR/BLI bimolecular interaction analysis platform Developed antibody characterization assays using DSC, DLS and HPLC techniques Co-lead two integrated therapeutic antibody discovery projects.
Postdoctoral Fellow
La Jolla Institute for Immunology
La Jolla, California, USA
Study Area: How invariant NKT cells recognize glycolipids antigens Technical Expertise: Receptor/ligand binding assay on Biacore, SEC and IEF; Protein Expression and Purification; X-ray Crystallography Publications: 1. Yali Li et al Galactose-modified iNKT cell agonists stabilized by an induced fit of CD1d prevent tumour metastasis (2011) EMBO J. 30(11):2294-305. 2. Yali Li et al The Vα14 invariant natural killer T cell TCR forces microbial glycolipids and CD1d into a conserved binding mode (2010) Journal of Experimental Medcine 207(11):2383-93. 3. Yali Li et al Lipid binding orientation within CD1d affects recognition of Borrelia Burgorferi antigens by NKT cells (2010) P.N.A.S. 107(4):1535-1540
Research Associate
Indiana University Bloomington
Study Area: Substrate recognition mechanism of molecular chaperone Technical Expertise: Protein Expression and Purification; Protein Biophysical Characterization: SEC, Circular Dichroism; Protein/ligand Binding Characterization using Fluorescence Polarization, ITC and Biacore; NMR
Education
Indiana University Bloomington
Biochemistry
University of Science and Technology of China
Chemistry
Yali Li's Contact Information
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