Xinxin Cheng

Chemical development and optimization of processes used in the manufacture of pharmaceutical intermediates and API's, non-GMP experience; R&D in multi-step organic synthesis of pharmaceutical intermediates and APIs; Utilization of a wide range of synthetic methods on gram to kilogram scale Familiar with enzyme catalysis screening, optimization of reaction conditions, and scale-up process. Good at research-based enzyme catalysis project types, project communication management. Leader of the biocatalysis team, serving high-throughput enzyme screening, biocatalysis process development. 100+ projects for FTE/GMP/non-GMP/commercial pharmaceutical intermediates or APIs using enzymes/biocatalysis;

Development and scaling up of popular molecular processes; API synthesis to quickly solve chemical problems. Familiar with enzyme catalyzed screening, optimization of reaction conditions, and scaling up of processes. Be good at research type enzyme catalysis project type and project Communications management.

According to the isosteric principle and active substructure splicing, the independent design includes hydroxyl protection and deprotection, nitration, reduction, and meerwein arylation. , condensation ring closure and other ten-step reaction routes, a series of substituted phenylpyrimidines and phenylpyrazoles were synthesized, and it was found that they not only have herbicidal effects as PPO enzyme inhibitors, but also their bactericidal and antitumor activities are also very common.