Xinbing Han

Job Scopes: Advanced Discovery Programs and Validated Targets in the Inflammation and Immunology Portfolio. • Initiated to identify and validate 7 new drug targets for inflammatory diseases. • Designed and developed in-vitro, ex-vivo, and in-vivo approaches to validate new targets and understand mechanism of action. • Established external scientific collaborations: Identified core risks in the toxicity/safety and provided a mitigation plan; Evaluated the feasibility of the new targets with PK/PD modeling. • Established and managed external scientific collaborations and CRO activities. • Collaborated with computational scientists and developed a differentiation strategy of targets using -omics data obtained from clinical trials with AI-powered data analysis. • Collaborated alongside cross-functional teams that included immunologists, computational scientists, chemists, biochemists, in vivo biologists, and transcriptomics and proteomics experts.

Job Scopes: Developed Assays for Preclinical Programs in Autoimmune Diseases • Delivered immunology and pharmacology, established various cellular, biochemical, and functional assays and technologies for drug discovery and preclinical programs in the portfolio, and characterized biologics and small molecule leads - Evaluated molecular mechanisms of action and drug-target pharmacology for 15 small molecule scientific programs and 3 biologics programs across from inception/start stage through Hit to Lead, Lead Optimization, and Pre-IND with multiple bioassays; helped advance 3 small molecule programs to preclinical development and 2 small molecule novel therapies to the clinic.

Job Scopes: Identified and Validated Therapeutic Targets for Inflammation, Diabetes, and Cardiovascular Diseases (CVD) • Investigated the regulation of cell differentiation and transcriptional mechanisms involved in linking metabolism to inflammation and diabetes and atherosclerosis using RNA-seq and proteomic array.

Job Scopes: Chemokine Receptors in Immune-Mediated Diseases and Cancer • Studied pathways and mechanisms associated with autoimmune disorders and cancer. Established bioassays for G protein-coupled receptor (GPCR) signaling and other functional assays. • Identified 2 constitutive active chemokine receptors for small molecule drug screening. Job Scopes: Innate Immune Function in HIV and Infectious Diseases-Epigenetic Modulation of Innate Immunity Activated by Single-Strand RNA (ssRNA) in HIV Infection • Investigated host-bacteria/virus interaction, virus RNA recognition and activation of innate immunity. Identified TLR8 as a potential novel therapy in the treatment of retroviral infection. • Isolated and cultured human primary immune cells, developed cellular assays (ELISA, antibodies) in vitro and ex vivo to analyze biomarkers in clinical samples, and developed RNA interference to study TLR8 signaling pathways in cells. Established technologies to detect epigenetic changes with ChIP assay.

Job Scopes: New Target Validation, Gene Therapy and Cell Therapy for Cardiovascular Disease (CVD) • Established cell-based in vitro and ex vivo systems. Identified and validated new therapeutic target (anti-inflammatory cytokine IL-10) and immune cell signaling. • Demonstrated the mechanism of action of cardiac gene therapies through in vitro and in vivo studies. Investigated new biomarkers and other outcome measures of safety and efficacy for use in gene therapy studies. • Developed a new hematopoietic stem cell (HSC)- and gene-based therapy for CVD with less impact on the general immune response in in vivo rodent model.