Xiaoyue Wu

•Conduct independent research on metabolic regulation of gastrointestinal tissue homeostasis, with a focus on NAD⁺ metabolism and host-microbiome interactions. •Design and execute in vitro and in vivo experimental studies to investigate mechanisms underlying gut inflammation, tissue stress responses, and disease progression. •Perform statistical data analysis and integrate multi-modal datasets to interpret complex biological outcomes. •Prepare manuscripts, presentations, and technical reports for internal and external scientific audiences. •Collaborate closely with interdisciplinary teams and core facilities in a highly regulated NIH research environment. •Mentor junior trainees and contribute to laboratory knowledge sharing and project coordination.

•Supported translational and clinical research projects involving nutrition-related interventions and gut microbiome analysis. •Contributed to experimental design, data analysis, and interpretation in hospital-based research settings. •Assisted with protocol development, regulatory documentation, and coordination between clinical and laboratory teams. •Applied statistical approaches to analyze experimental and clinical datasets.

•Investigated how gut bacteria enhance mammalian NAD⁺ metabolism through the deamidated biosynthesis pathway. •Conducted molecular and cellular experiments to elucidate host-microbe metabolic interactions. •Analyzed experimental data and contributed to findings that informed subsequent mechanistic studies.

•Dissertation research focused on the molecular mechanisms of acrolein-induced atherosclerosis, with emphasis on plasma lipid metabolism and gut microbiota regulation. •Conducted experimental and mechanistic studies integrating nutritional biochemistry, molecular biology, and microbiome analysis. •Developed strong expertise in nutritional metabolism, disease biology, and data analysis within a medical school-based School of Public Health.

•Completed undergraduate research analyzing determinants of neonatal birth weight across urban and rural populations in Henan Province. •Gained foundational training in epidemiology, biostatistics, and public health research methods, providing context for later mechanistic research.