Xianrui Z.

Associate Director @ Stealth Startup

About

Self-motivated professional with more than 10 years experience in medicinal chemistry; experts in organic synthesis and analysis; innovative design of new chemical entities utilizing computational tools; proficient in small molecule drug discovery (HTS screening, lead optimization, PK/PD and clinical candidate nomination); projects covering oncology (kinase) and CNS targets, as well as infectious diseases and cancer immunotherapy areas; skillful in managing CRO (FTE and/or FFS). Professional Skills: Organic synthesis; medicinal chemistry; heterocyclic chemistry, combinatory chemistry, peptide chemistry, natural product chemistry, and pro-drug and drug delivery system; Structure-activity relationship (SAR) data mining and scaffold-hopping; Computer-aid drug design (CADD), including FBDD, SBDD and PBDD; Hands-on experience with LCMS, HPLC, NMR (including 2-D), etc. Motto: Live as if you were to die tomorrow. Learn as if you were to live forever. by Mohandas K. Gandhi (India) 有志者,事竟成,破釜沉舟,百二秦关终属楚. 苦心人,天不负,卧薪尝胆,三千越甲可吞吴. 原作:蒲松龄 (中国)

Country

United States

City

San Francisco Bay Area

Industry

Biotechnology

Skill

Drug Discovery, Organic Chemistry, Analytical Chemistry, Organic Synthesis, Drug Delivery, Drug Design, Medicinal Chemistry, Combinatorial Chemistry, Computational Chemistry, Heterocyclic Chemistry, Mass Spectrometry, SAR Data Analysis, Peptides, Natural Products, R&D, Lead Optimisation, Fragment-based drug design, Structure-based drug design, CRO and FTE management, Protein Chemistry

Experience

Associate Director

Stealth Startup

2025-7 - Present · 1 yr 3 mos

Small molecule inhibitors and PROTAC molecules.

Associate Director

Vicinitas Therapeutics

2023-5 - 2025-3 · 1 yr 11 mos

South San Francisco, CA

Investigation in DUBTAC concept and design of novel bRo5 molecules for PoC and application; developing covalent hit/fragment into high affinity covalent inhibitor/ligand with good selectivity.