Xiang Li

Principal Scientist, siRNA ex-hepatic delivery and therapeutics @ AbbVie

About

Experienced Research Scientist with studying on oligonucleotide therapeutics. -Over 9 years research experience on DNA/RNA nanotechnology and its pharmaceutical applications . -Professional experience on designing, fabrication and characterization of nucleic acid based drug delivery systems and synthetic nucleic acid vaccines. -Solid knowledge in fabrication and characterization of bio/nano material. -Extensive experience on biochemistry and molecular biology. (Cell culture and transfection, Western Blot, PCR, Gel electrophoresis, ELISA, DNA/RNA extraction, DNA/RNA conjugation, etc.) -Well-trained techniques on analytical chemistry. (HPLC, capillary electrophoresis, dynamic light scattering, fluorescence microscopy, atomic force microscopy, UV-Vis, FTIR, Nanodrop) -Adept user for programming and data analysis software (Matlab, Prism, ImageJ ) -Good documentation skill for data summarization and SOP writing; good understanding of cGMP and lab safety. Over 4 years experience as department safety committee representative for the lab during PhD study.

Country

United States

City

Boston

Industry

Biotechnology

Skill

Microsoft Word, Microsoft Excel, Microsoft Office, Research, PowerPoint, C++, Java, Public Speaking, Teamwork, Customer Service, Photoshop, Teaching, Matlab, Data Analysis, Nanotechnology, Statistics

Experience

Principal Scientist, siRNA ex-hepatic delivery and therapeutics

AbbVie

2025-9 - Present · 1 yr 1 mo

United States

Director, Discovery Research

Entrada Therapeutics

2023-6 - 2025-9 · 2 yrs 4 mos

Associate Director, Discovery Research

Entrada Therapeutics

2021-12 - 2023-5 · 1 yr 6 mos

Boston, Massachusetts, United States

Senior Research Scientist

Entrada Therapeutics

2019-8 - 2021-12 · 2 yrs 5 mos

Greater Boston Area

Applied Research Scientist

InfinixBio

2017-11 - 2019-7 · 1 yr 9 mos

Columbus, OH, USA

Downstream development of therapeutic protein drug or antibody, including the expression, purification, conjugation and scale-up of company’s products. Development of analytical methods for QA/QC of the protein products by mass spectrometry, HPLC, FPLC, western blot, ELISA and a number of enzymatic assays.

Research Scientist

Parabon NanoLabs Inc.

2015-9 - 2017-11 · 2 yrs 3 mos

Huntington, West Virginia

Research on design, preparation, optimization and characterization of nucleic acid based nanostructures for pharmaceutical applications. 1. Lead development and qualification of a synthetic, highly modular DNA vaccine construct containing both the functional gene cassettes and targeting molecules for selectively gene delivery in desired cells. 2. Lead the characterization and optimization of physical properties of a series nucleic acid/polymer nanostructure formation by dynamic light scattering, confocal microscopy and atomic force microscopy. 3. Prepare and purify of conjugated nucleic acid generated from click-chemistry. 4. Develop QA/QC protocols for analytical methods in the company. 5. Generate and update high-quality documentation of SOPs and technical reports. 6. Actively involved in proposal writing, project designing, and bring technical support for rest of the team.

Postdoc Fellow

University of Michigan

2014-8 - 2015-9 · 1 yr 2 mos

Ann Arbor

Researched on application of single-molecule fluorescence microscopy technique for the characterization of DNA/RNA nanostrucrures and inorganic nanomaterials. 1. Studied on the detection, kinetic measurement and data analysis of DNA/RNA molecules at single molecular level by DNA PAINT method. 2. Characterized the 3D structure of porous nano-material with fluorescence labeled DNA nanostructures as probes by single molecule microscopy.

Education

Tsinghua University

Chemistry and biology

2005 - 2009 · 4 yrs

Researched on titanium dioxide nano-structures and composite material to improve the photovoltaic performance for novel solar cells and develop their application for bio-molecule detection. 1. Developed a titanium dioxide nano-array based photoelectrochemical assay for biomolecule detection. 2. Enhanced the photoelectrochemical property of titanium dioxide with versatile nano-structures for better performance solar cells and pollutant degradation catalyst.