Xi Ai
Principal Scientist @ Merck
About
SUMMARY OF QUALIFICATIONS Pharmaceutical R&D scientist with 5+ years of experience in drug discovery from target validation through lead optimization. • 20+ years of hands-on laboratory research experience in Molecular Biology, Biochemistry and Cell Biology. • Extensive experience and achievement on assay development, compound screening, protein trafficking, target identification & validation, and mechanism of action studies. • Publishes regularly in prestigious, well-known journals, including Molecular Cell. • Excellent team player, displaying adaptable, pleasant personality. Specialties: Atherosclerosis, Biomarker, Cell Death (Apoptosis), Diabetes, Assay Development & Compound Screening, Chromatin Assembly, Histone Modification, Crystallography
United States
New York City Metropolitan Area
Pharmaceuticals
Atherosclerosis, Cell Death, Biomarkers, Protein Expression, Crystallography, Diabetes, Assay development, Cell Biology, Protein Chemistry, Molecular Biology, Assay Development, Drug Discovery, Biochemistry, In Vitro, Cell Culture, Life Sciences, Pharmacology, Cell, DNA, Biotechnology
Experience
Principal Scientist
Merck
Kenilworth, New Jersey, United States
Screening and compound profiling
Associate Principal Scientist
Merck
Kenilworth NJ
Screening and compound profiling
Associate Principal Scientist
Merck
In Vitro Pharmacology rep for TIDV programs
Associate Principal Scientist
Merck
Atheroscelorosis Department, Division of Cardiovascular Diseases - Mechanism of action (MOA) studies. - Novel target identification and validation in Atherosclerosis. - Coordination of external collaborations. - Liaison of External Scientific Affair, coordination of agreement and licensing activities on Atherosclerosis external collaborations.
Senior Research Biologist
Merck
Atheroscelorosis Department, Division of Cardiovascular Diseases Apoptosis Research Group - Mechanism of action (MOA) studies. - Leading Assay development and hit finding effort on atherosclerosis related target. - Novel target identification and validation in Atherosclerosis. - Coordination of external collaborations. - Generation and characterization of antibodies specific for caspase-cleaved neo-epitopes. - “-Omics”studies to identify universal responsive apoptosis biomarkers (metabolomics & glycomics). - Development of cell-death models.
Post-doctoral researcher
Princeton University
Dr. Virginia Zakian’s Laboratory, Dept. of Molecular Biology Projects: 1. Purification and characterization of a novel eukaryotic helicase 2. Role of the human PIF1-like DNA helicase in maintaining genome integrity
Post-doctoral researcher
The Ohio State University
Dr. Mark Parthun’s Laboratory Projects: 1. Characterization of a novel histone core domain acetylation and its affects on chromatin assembly and gene silencing 2. The effects of histone modification on the forming of euchromatin and heterochromatin
Graduate Research Associate
The Ohio State University
Department of Molecular and Cellular Biochemistry 1.Identification and characterization of a novel chromatin assembly factor Hif1 2.Role of Hat1p-containing histone acetyltransferase complex in chromatin assembly Department of Chemistry and Dept of Plant Biology 1. The study of structural and functional relationship of photosystem II 2. Novel strategies for crystallization of membrane proteins
Graduate Teaching Associate
The Ohio State University
Department of Chemistry 1. Teach undergraduate level general chemistry classes and lab. 2. Help teach graduate level biochemistry classes.
Graduate Research Associate
Institute of Biophysics, Academy of Chinese Sciences
Crystallographic study of insulin allosteric intermediate (T3R3 state) induced by different small organic molecules
Research Assistant
Academy of Military Medical Sciences, Beijing, P.R. China
Institute of BioEngineer 1. Development of monoclonal antibodies against prourokinase 2. Pre-clinical research on recombinant prourokinase 3. Bioprocess development of therapeutic proteins
Education
The Ohio State University
Biochemistry
2004 Travel Award for Poster Presentation, Graduate and Postgraduate Research Day, School of Medical Sciences, The Ohio State University, Columbus, Ohio 2003 Finalist, OSBP Autumn Symposium, The Ohio State University, Columbus, Ohio 2003 Best Scientific Presentation, 3rd annual retreat, Department of Molecular and Cellular Biochemistry, The Ohio State University, Columbus, Ohio 1997-1998 Fellowship, Graduate School, The Ohio State University, Columbus, Ohio
Wuhan University
Cell Biology
1992 Outstanding Graduate, Wuhan University, Hubei, P.R. China 1992 First and Second Prize, Excellent performance in theatrical performance, Wuhan University, Hubei, P.R. China 1989 Top Ten Campus Singers, Wuhan University, Hubei, P.R. China 1989-1992 Excellence in Leadership of Student groups, Wuhan University 1988-1992 Fellowship, Wuhan University, Hubei, P.R. China 1988-1992 Outstanding Student, Wuhan University, Hubei, P.R. China
Xi Ai's Contact Information
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