Wei Jiang

• Designed and built a fully integrated automation platform for antibody discovery (Single B) • Participated in a pipeline targeting cancer with antibody, completed lead candidate screening • Initiated a pipeline targeting autoimmune disease with antibody oligo conjugates (AOC) • Actively involved in external evaluation of technology platforms, especially antibody and RNA related technology, established 5 MTA with local biotechs

• Established Protein Sciences lab from 0-1, including SOP establishing, lab design, instrument order, technician recruitment and management • Designed and built 3 automation islands: molecular biology, antibody expression and purification, antibody characterization. These systems have been validated to process 400 mAbs per week

Project leader in Protein Sciences Department. Served 20+ international client for antibody drug candidates generation and screening

Project: Investigating mechanistic process of CRISPR-Cpf1 system • Developed in-vitro assay to assess off-target effect of CRISPR-Cpf1. • Expressed and purified Cpf1 protein, engineered Cpf1 protein function by mutagenesis. • Designed CRISPR RNA by in-vitro transcription. • Studied DNA early interrogation mechanism with Cpf1/RNA enzyme. Project: Investigating function roles of RNA elements on CRISPR-Cas9 activation • Engineered RNA function by designing sgRNA mutants. • Demonstrated the ability of sequence-specific recognition of sgRNA/Cas9 complex. • Studied the effect of RNA functional elements on CRISPR-Cas9 using site-directed spin labeling (SDSL) and biochemical assay.

• Biochemistry 330 (lab) :Head teaching assistant • General Chemistry 105a, b (lab) • Organic Chemistry 322b (lab) • Chemical Forensics: The Science, and Its Impact 205 (lab and discussion)

Project: Synthesis of In2Se3 and Bi2Se3 two-dimensional nanoplates. • Synthesized single crystal In2Se3 and Bi2Se3 nanoplates using a PVD system. • Designed In2Se3 and Bi2Se3 based optoelectric devices and characterized electronic functions of 2D materials. Project: Design of controllable and facile 2D material fabrication process. • Achieved patterned growth of various 2D material nanoplate arrays with uniform shape, thickness, orientation, periodicity and size. • Studied the growth mechanism for the controlled growth on modified mica. Project: Design of nanostructures based on the controllable fabrication process. • Achieved the patterned interfacial heterogeneous In2Se3 /Bi2Se3 and In2Se3/Graphene by controllable growth and micro-transferring methods. • Characterized the heterogeneous structure via Raman spectroscopy.

• Special topics of chemistry (discussion)