Wei-Sheng Chen
Director @ Osanni Bio
About
Skilled and passionate research scientist and drug developer with expertise in cell biology and animal studies, including 7 years of experience in pharma and 3 years as post-doc. Talented and motivated researcher with track record leading programs with solid technical background traversing several human diseases, including neurodegenerative ocular, infectious, and cardiovascular. Seasoned project leader exceptionally proficient with in vivo pharmacology and rodent models of ocular diseases, cell-based assays, and molecular biology techniques. Collaborative team player adept at leading and working on cross-functional research projects in biopharma and biotech across diverse drug platforms. Project Management | Decision Making | Strategic Planning & Analysis | Experiment Design & Planning Time Management | Hypotheses & Results | Troubleshooting | Can-Do Attitude | In Vitro/Ex Vivo/In Vivo Skills
United States
San Leandro
Pharmaceuticals
Scientific Reports, Study Monitoring, Primates, Statistics, Patent Applications, Analytical Skills, Statistical Analysis, Organoids, Oligonucleotides, Neurodegenerative Disease, Program Management, Time Management, Cell Biology, Time-efficient, Western Blotting, Project Management, Molecular Biology, Cell Culture, Biochemistry, Biotechnology
Experience
Director
Osanni Bio
San Francisco, CA
Director
Vial
Led cross-functional drug discovery programs for liver siRNA and CNS antisense oligonucleotides (ASO) from hit ID to preclinical candidates, working with fast-paced teams to advance therapeutic candidates.
Principal Scientist
Vial
Associate Principal Scientist
Hansoh Bio
Rockville, Maryland, United States
Supported cross-functional drug discovery programs for liver siRNA during target ID, working with fast-paced teams to advance therapeutic candidates. • Managed Contract Research Organization (CRO) for mouse and non-human primate (NHP) studies, resulting in real-time data reports for patent applications.
Senior Scientist
Johnson & Johnson Innovative Medicine
San Francisco, California, United States
Led cross-functional drug discovery programs for ocular siRNA from lead optimization to preclinical development and supported 2 other siRNA programs, utilizing cutting-edge technologies and methodologies to advance therapeutic candidates.
Scientist
Johnson & Johnson Innovative Medicine
South San Francisco, California, United States
Served as 1of discovery team's founding member. Led a cross-functional drug discovery program for ocular siRNA from target selection to lead optimization and a program for ocular antibody, utilizing cutting-edge technologies and methodologies to advance therapeutic candidates.
Scientist I
NGM Biopharmaceuticals
San Francisco Bay Area
Established in-house preclinical pharmacodynamics (PD) studies of ocular diseases from scratch and managed in vivo studies of 2 ocular projects within Biology group. Generated preclinical in vivo data enabling Investigational New Drug (IND) filing of NGM621, an anti-C3 antibody for geography atrophy.
Postdoctoral Fellow
National Institute of Allergy and Infectious Diseases (NIAID)
Bethesda, MD
Conducted translational research to study pathogenesis of rare disease, Systemic Capillary Leak Syndrome.
Postdoc fellow
New England Eye Center
Boston, MA
Utilized mouse models of corneal neovascularization, dry eye, laser-induced choroidal neovascularization, and experimental autoimmune uveitis to examine galectins’ role in ocular diseases.
Graduate student
Tufts University School of Medicine
Boston, MA
Researched and studied the role of galectins in ocular diseases, including neovascularization, glaucoma, age-related macular degeneration, and allergic eye diseases.
Assistant Research Scientist
CUNY School of Medicine
Tuxedo Park, NY
Skillfully extracted DNA from tissues and primary cells and assessed acrolein-induced DNA damage and repair of mitochondria DNA for epigenetic studies. Utilized E. coli expression system to express DNA repair proteins including Fpg, UvrA, UvrB, and UvrC.
Research Assistant
National Cheng Kung University
Tainan, Taiwan
Education
Tufts University School of Medicine
Cell, Molecular & Developmental Biology Program
Ophthalmology Department.
National Cheng Kung University
Biochemistry and Molecular Biology
National Cheng Kung University
Medical Laboratory Science and Biotechnology
Internship at Department of Pathology, National Cheng Kung University Hospital. 9/2003 to 1/2004. Rotate at clinical biochemistry lab, clinical hematology lab, clinical microbiology lab, clinical blood bank lab, clinical virology lab, clinical cytology lab, and clinical physiology lab.
Wei-Sheng Chen's Contact Information
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