virginie williams

* Research Project: Analyzed the role of hepatitis Delta virus proteins in development of hepatocellular carcinoma. --» Characterize HDV protein role as regulator of cell homeostasis function. --» Study regulation of IFN induced gene by HDV protein. Responsabilities: * Design and perform experiments for the development of my project, interpretation of results, data analysis * Contribution in grant application * Teach lab techniques to undergraduate students * Presentation to national and international congress * Write manuscript for publications

* Research Project: Oncogenic signaling pathways in breast cancer : regulation and function of the IKKepsilon kinase. * Responsabilities: * Prepare application to obtain permit from government agencies (Health Canada, ACIA) * Participate in obtaining ethical protocol amendment * Contribute in writing funding proposal for scientific institutions and scientific articles for * international peer review journal, generating preliminary data for grant applications. * Responsible for orders management, ensure maintenance and inventory forecasting, * coordinate contact with representative of various companies and hospital buyers * Perform molecular biology and biochemistry experiments * Test inhibitors inducing death in breast cancer cell lines * Use of a cohort of patients with breast cancer to study correlation between IKKepsilon kinase and * clinical data

* Research Project: Molecular mechanisms of anti-tumour function of Stat1 in ErbB2 mediated transformation and implications in mammary gland tumourigenesis. * » Demonstrate that Stat1 acts to suppress Neu-mediated breast tumorigenesis through * immune regulatory and tumor-site specific mechanisms. * » Characterization Stat1 anti-tumor activity in ErbB2/Neu-mediated cell transformation with possible implications in the diagnosis and treatment of ErbB2-positive breast cancer. * Responsabilities: * Supervise one student and one staff member (lab manager). * Establish mouse orthotopic model in the laboratory in order to understand the role of * Stat1 inhibition in ErbB2 oncogenesis. * Design and Perform experiments in molecular biology, biochemistry and with transgenic mouse. * Annotate and bank mouse samples for use in molecular biology and immunochemistry * research.

The hepatitis Delta virus: inhibition of hepatitis B virus replication; Approach of specific molecular mechanisms of hepatic pathogenesis

Research Experience: Analyzed of mechanisms of hepatitis B virus inhibition by hepatitis Delta virus.

Research Experience: Analyzed the distribution of hepatitis B virus genotypes in Seine Saint Denis district by molecular biology techniques.