Tingting Yuan, Ph.D.

• Design and execute/conduct in vitro or in vivo studies to facilitate drug discovery and development; • Participate in new target identification and validation; • Present research findings to project teams and governance bodies and prepare technical reports. • Maintains a high level of productivity in the lab and perform critical experiments. • Mentors and supervises a team of one or more and guide and evaluate the performance of those individuals and am accountable for the effective performance of the team.

Funded by a self-submitted grant from Cystic Fibrosis Foundation. Expertise in the research of mechanisms Idiopathic Pulmonary Fibrosis (IPF) and other interstitial lung diseases. Led independent research efforts for publications and grant submission. Designed and implemented strategies for research projects directed toward lung development and lung diseases. Organized and led work efforts for laboratory responsibilities and development of chemical hygiene plans. • Published 3 research papers in high profile journals with 2 first-authors credits in Dev Cell, Stem Cell Reports showing high productivity and efficiency. • Wrote and published 1 review paper on the topic of FGF10 signaling during lung development, injury and diseases in Frontiers in Genetics in 2018. • Explored 10Xgenomics Single-Cell RNA-Seq on lung epithelial cells and analyzed the data for the research paper. • Mentored and guided 2 Ph.D. students and one part-time graduate student to be independent to do bench work. • Optimized the lab management systems including lab equipment instructions, experimental protocols, and improved lab efficiency. • Finished graduate courses of total 15 credit hours for graduate-level “Mentoring and leadership” Certificate.

Investigated the role of FGF10 as a potential therapeutic target for Idiopathic Pulmonary Fibrosis (IPF) patients using mouse models for bleomycin injury. Collaborated on projects for research efforts directed towards the mechanisms of WNT and FGF10 signaling pathways during lung development and lung stem cell regeneration after lung fibrosis injury. • Obtained strong hand-on skills working on mouse model including breeding strategy for conditional knock-out/overexpressed mouse strains, dissection, trachea instillation, etc. • Developed a strong knowledge background of lung development and lung disease models. • Generated data for multiple research projects efficiently.

Performed research work efficiently and generated data. Used CRISPR/CAS9 Knock-in gene correction in a mechanism study of rare human diseases caused by site mutations on specific genes. Closely worked with a high-efficient team in the lab with multiple projects. Assisted PI with finishing budget documents for multiple grants with tight deadlines. Exceeded expectations through high productivity on establishing new experimental systems, presenting project design and results, mentoring students and helping colleagues. • Published 8 research papers within one year and 8 months including high profile journals Science, Cell Stem Cell, Cell Research showing high productivity. • Established multiple experiment systems for the laboratory: Including CRISPR/CAS9 gene targeting in hESCs, DIG-labeled Southern Blot, FISH, FISH-IF, Q-FISH. • Contributed significant data on human aging disease project-Werner syndrome using the stem cell model and published the findings in Science. • Devoted statistical analysis on the project of genome editing in human pluripotent cells in human disease models and pushed the finding published in Cell Stem Cell.

Ph.D. in Cell Biology, Dissertation: The mechanism study of the components and developmental regulation of LFR-containing SWI/SNF chromatin remodeling complex Supervisor: Prof. Sujuan Cui

B.S. in Bioscience-“Excellent thesis honor of University”