Songjun Xiao, PhD
Process Development senior scientist @ Axolabs
About
• Passionate and self-disciplined bioorganic chemist interested in DNA/RNA chemistry and chemical biology as well as biomaterials. • Highly interdisciplinary background ----sequencing oxidative modifications in DNA via enzymatic reaction and bioconjugation ----studying the influence of oxidative DNA damage on gene transcription in mammalian cells ----design and synthesis of soft materials for applications such as environmental remediation, water purification, biomedical device, therapeutic treatment and rewritable hydrogel systems. • Experienced in a wide range of techniques, from HPLC, organic synthesis and spectroscopic analysis (NMR, MS, ICP-MS, UV-Vis, IR), to biochemical assays like polymerase chain reactions (PCR), gel electrophoresis and cell culture. • Interested in interdisciplinary projects and effective in scientific communications and presentations. • An avid traveler. • Willing to relocate for new opportunities.
United States
Petaluma
Biotechnology
Solid Phase Synthesis, Project Management, High-Performance Liquid Chromatography (HPLC), Polymerase Chain Reaction (PCR), Oligonucleotides, Nuclear Magnetic Resonance (NMR), Gel Electrophoresis, Organic Synthesis, Mammalian Cell Culture, Bioconjugate Chemistry, Environmental Science, UV/Vis Spectroscopy, Data Analysis, Scanning Electron Microscopy, Gas Chromatography, Mass Spectrometry, Organic Chemistry, Scientific Writing, Analytical Chemistry, Nanotechnology
Experience
Process Development senior scientist
Axolabs
Petaluma, California, United States
• Oligonucleotide synthesis on the μmol to mmol scale using AKTA OligoPilot, including single guide RNAs (sgRNA), aptamers and antisense oligos (ASO) containing modifications such as 2’-F, 2’-OMe, GalNAc etc. • Optimized sgRNA desilylation reactions for easier and safer manufacturing at large scale while reducing organic solvent usage • Purification of oligos using reverse-phase and ion-exchange chromatography • Identification and characterization of oligonucleotide impurities from IPRP-HPLC chromatograms • Routine oligo handling including cleavage/deprotection, conjugation, hybridization, desalting and lyophilization
Postdoctoral Research Fellow
University of Utah
Salt Lake City, Utah, United States
-Improved a method for sequencing oxidative damage in DNA using click chemistry coupled to based excision repair -Synthesized and purified ribonucleotide triphosphates for in vitro transcription assay -Discovered the phototoxicity of common G-quadruplex ligands on guanine-rich DNAs -Studied the influence of oxidative DNA damage caused by G-quadruplex ligands on gene transcription in HEK 293T cell line -Confirmed the photooxidation of G-quadruplex DNA with commonly used fluorescent dyes -Synthesized two Ir(III) photooxidants and studied the photooxidation of guanine-rich DNA -Utilized aldehyde reactive probe to detect uracil damage coupled to base excision repair
Graduate Research Assistant
University of Maryland
Washington D.C. Metro Area
-Designed and characterized a guanosine hydrogel with potential for remediation of toxic dye, absorption of carcinogenic electrophile, and biomedical applications -Synthesized more than 40 different guanosine analogs over multiple steps and examined their hydrogelation properties -Discovered 3 intermediates in the oxidative desulfurization of biologically relevant 8-thioguanosine and identified a redox-responsive hydrogel -Designed a rewritable hydrogel system using innocuous natural products -Mentored multiple undergraduate students doing research -Presented research at national (Washington, DC) and international conferences (Cambridge, UK)
Graduate Teaching Assistant
University of Maryland
Washington D.C. Metro Area
-Discussion teaching assistant (Organic Chemistry I & II) -Laboratory teaching assistant (Organic Chemistry I & II) -Mentored undergraduate students conducting special research projects -Completed a full lecture about ether and epoxide chemistry (Lecturer: Dr. Taylor Plank)
Undergraduate Research Assistant
Nankai University
Tianjin City, China
-Guided National Training Programs of Innovation and Entrepreneurship for Undergraduates -Utilized pH responsive low-molecular-weight organic hydrogel for controlled drug release
Education
University of Maryland
Supramolecular hydrogels, bioorganic chemistry
Nankai University
Chemistry
University of Utah
DNA damage
Songjun Xiao, PhD's Contact Information
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