Snehasish Ghosh

During my Ph.D., I developed nature-inspired peptide sealants for wound healing and trauma care. By integrating fibrin-mimetic self-assembly with mussel-inspired wet adhesion chemistry, I created biomaterials that surpass conventional fibrin glues in adhesion, clotting efficiency, and biocompatibility. I validated these sealants through ex vivo and in vivo studies, along with structural and biochemical analyses. My work connects chemistry, materials science, and biology to design advanced therapeutic biomolecules for surgical and trauma applications. Having a solid interdisciplinary background is one of my key advantages. My PhD in the interface of Chemistry and Biology from the Indian Institute of Science Education and Research at Kolkata, one of India's leading science institutes, has helped me broaden my knowledge and explore new perspectives in addressing critical problems. Coming from a multicultural society in India, I am also highly adaptable and can easily manage various roles. Connectedness and empathy are my strengths; I am a team player and bring a positive attitude. As a postdoctoral associate in Yale's Department of Cell Biology, I am pioneering new methods to synthesize peptides and polymers that enable spatially precise extraction of membrane proteins into native membrane nanodiscs. These innovative nanodiscs open the door to advanced applications, including TIRF microscopy, mass spectrometry, and structural analysis, empowering researchers to explore membrane proteins in their native context. For a deeper dive, check out my recent publication: https://www.nature.com/articles/s41592-024-02517-x. In the long term, I see myself as an active contributor to research and development. My vision is to solve real-life scientific problems in biosciences, contributing to the value-based economy and society at large. Additionally, I wish to be involved in outreach activities to create awareness and general interest in science.