Siyuan (Melanie) Wu
PhD Student in Molecular & Cellular Biology @ University of Massachusetts Amherst
About
🔬I’m a Ph.D. candidate in the Molecular and Cellular Biology program at UMass Amherst, where I study Fusarium oxysporum, a cross-kingdom fungal pathogen capable of causing life-threatening infections in humans. Under the supervision of Dr. Li-Jun Ma, my research integrates comparative genomics, proteomics, and RNA technology to uncover host-pathogen interactions and develop RNAi-based antifungal therapies—an innovative strategy bridging fundamental science and translational medicine. 🚀At UMass, I'm a trainee in the NIH-funded Biotechnology Training Program, which equips scientists with the skills to translate research into real-world biomedical solutions. I’m also a scientific co-founder of VeriMyco, a therapeutics spinoff from the Li-Jun Ma Lab, focused on developing RNAi-based antifungal drugs targeting human-pathogenic fungi. In parallel, I participated in the NSF I-Corps Regional program as part of the founding team of Limbus 2020, a stem cell therapy startup. These experiences have sharpened my understanding of customer discovery, regulatory pathways, and early-stage biotech commercialization. 🌐Outside of the lab, I serve as the Design Lead for the Chinese Antibody Society, where I help organize national scientific conferences and global biotech forums. I’m passionate about fostering interdisciplinary collaboration and promoting innovation in genomics, infectious disease, and therapeutic development. 📌I’m always eager to connect with researchers, clinicians, entrepreneurs, and industry partners who share an interest in RNA therapeutics, fungal pathogenesis, and translational science. Let’s explore opportunities to collaborate, innovate, and make an impact.
United States
Amherst
Biotechnology
Functional Genomics, Computational Genomics, Translational Research, Volunteering, Communication, Management, Public Speaking, Computer Science, Computer Architecture, Genetics, Bioinformatics, Molecular & Cellular Biology, Immunology, Host-pathogen Interactions, Graphic Design, Computer-Aided Design (CAD)
Experience

PhD Student in Molecular & Cellular Biology
Amherst, Massachusetts, United States
I am a doctoral researcher in Molecular and Cellular Biology at UMass Amherst, working in Dr. Li-Jun Ma’s lab, where we leverage comparative genomics to investigate fungal pathogens, with a special focus on Fusarium oxysporum, a cross-kingdom fungal pathogen. My research centers on the human-pathogenic strains of F. oxysporum, which are capable of causing infections ranging from superficial skin conditions to life-threatening systemic diseases. Using a combination of comparative genomics, proteomics, and molecular biology techniques, I explore key questions related to pathogen adaptation in mammalian hosts and host-fungal interactions. A critical aspect of my work is the design and development of RNA interference (RNAi)-based therapeutics aimed at combating this challenging infectious disease.

Technical Research Assistant
Boston, Massachusetts, United States
Harvard Medical School, Brigham and Women's Hospital, Division of Genetics Research Assistant in Dr. Natasha Frank's Lab - Utilize molecular biology techniques and bioinformatics computational tools to investigate the role of ATP-binding cassette subfamily B member 5 (ABCB5) in cancer cell regulation, stem cell therapy and wound healing

Teaching Assistant
Boston College Computer Science Department
Chestut Hill, MA
Assist professor and lead student lab sessions for Computer Organization course

Student volunteer
Boston College, Student Admission Office
- Eagle For A Day host, AHANA Weekend host, Greeting Staff, International Outreach - Host prospective minority students and arranged them to attend interested classes with BC professors - Inform prospective students and parents with an in-depth look at the everyday life of a BC student - Represent an accurate image of Boston College’s current students and the admission program
Siyuan (Melanie) Wu's Contact Information
Phone
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