Siyeon (Sia) Im

Cheminformatics, Associate Scientist @ Wave Life Sciences

About

I am a highly motivated and independent chemist with 3 years of industry experience in the design and synthesis of small molecules for structure-activity relationship (SAR) studies of RNA delivery. Additionally, I worked on bioconjugation and cheminformatics projects. Prior to working in industry, I did my M.S. in computational chemistry where I studied the underlying molecular design principle of bioimaging molecules using computational quantum chemical tools. Visit my medium page to read up on my insights + code in cheminformatics: https://medium.com/@siyeon999

Country

City

United States

Industry

Biotechnology

Skill

Bioconjugation, Lipid chemistry, Bioorthogonal chemistry, Multi-step Synthesis, Cheminformatics, Machine Learning, Data Science, DFT, Python (Programming Language), excited state, Research, Computational Chemistry

Experience

Cheminformatics, Associate Scientist

Wave Life Sciences

2025-5 - Present · 1 yr 5 mos

Cambridge, Massachusetts, United States

Associate Scientist

Intellia Therapeutics, Inc.

2024-7 - 2025-1 · 7 mos

- Explored and optimized various bioconjugation strategies and linkers on proteins - Synthesize, purify, and characterized novel lipids to be formulated into lipid nanoparticles (LNPs) for mRNA delivery - Identified highly efficacious lipid for hepatic and extrahepatic delivery, resulting in a patent application - Develop structure-activity relationships (SARs) and design lipids with optimal delivery properties

Senior Research Associate

Intellia Therapeutics, Inc.

2021-10 - 2024-7 · 2 yrs 10 mos

- Spearheaded automation and consolidation of chemical databases using cheminformatics techniques, presented in company-wide meetings - Closely collaborated across five different teams ranging from biology to software engineering teams