Si-Jie CHEN, Ph.D.
Senior Principal Investigator @ BeOne Medicines
About
My Ph.D. research focused on developing copper-catalyzed cross coupling reactions of benzylic C–H substrates and various nucleophiles, where I developed my project management mindset in general, as well as synthetic skillset and analytical techniques. Through extensive collaboration with scientists from both academia and industry, these projects have led to many publications in high-impact journals. My further engagement in high-throughput experimentation (HTE) and cheminformatic allowed me to connect synthetic methodologies with the modern chemistry capability and drug discovery efforts. Afterwards, I have joined Merck & Co., Inc. and focused on development of antibody-drug conjugates (ADC) for oncology applications.
China
Guangzhou
Pharmaceuticals
Data Science, Communication, Organic Synthesis, Nuclear Magnetic Resonance (NMR), Teaching, Liquid Chromatography-Mass Spectrometry (LC-MS), Chromatography, Homogeneous Catalysis, Air-sensitive Synthesis, Electron Paramagnetic Resonance (EPR)
Experience
Senior Principal Investigator
BeOne Medicines
廣州
Guest Speaker/Adjunct Professor
Ajou University
South Korea
Senior Scientist II
Merck
South San Francisco, California, United States
Senior Scientist
Merck
South San Francisco, California, United States
Developed linker-payload platforms for antibody-drug conjugates (ADC), focusing on synthesis of highly potent, water-soluble cytotoxic (linker-)payloads, and established high-throughput chemistry capabilities for small molecule and bioconjugate applications
Visiting Scientist
Merck
Kenilworth, New Jersey, United States
Visit Merck as part of the Merck-Stahl collaboration for research on benzylic C–H functionalization strategies with high-throughput experimentation (HTE) and cheminformatics
Research Assistant
University of Wisconsin-Madison
Madison, Wisconsin Area
Developed copper-catalyzed benzylic C–H cross coupling reactions via a redox buffering strategy in Prof. Shannon S. Stahl's group.
Student Research Assistant
The Hong Kong Polytechnic University
Hong Kong
Research on ruthenium- and palladium-catalyzed cross coupling reactions
Education
University of Wisconsin-Madison
Organic Chemistry
Graduate student in chemistry working on Copper-catalyzed C-H functionalization in Prof. Shannon S. Stahl's group and collaboration with Merck
The Hong Kong Polytechnic University
Department of Applied Biology and Chemical Technology
Undergraduate researcher working on Ru-catalyzed olefin difunctionalization in Prof. Michael Wing-Yiu Yu's group
Sun Yat-sen University
Chemsitry（2+2）
Si-Jie CHEN, Ph.D.'s Contact Information
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