Shuang Zhou

Product Strategy – Lead global product lifecycle management, commercialization, and portfolio optimization. Marketing & Growth – Develop branding, digital campaigns, and distributor partnerships to expand market reach. Operational Excellence – Oversee logistics, supply chain, and GMP compliance for efficiency and quality. Cross-Functional Leadership – Collaborate with R&D, sales, and technical teams to align innovation with market needs. Team Development – Manage and mentor product managers, marketers, and scientists for high-impact execution.

Topic Editor: “Evidence-based Advance and Management of Adverse Events of Immunotherapy for Cancer”; Journal: Frontiers in Pharmacology. Impact Factor: 3.831 https://www.frontiersin.org/research-topics/8916/evidence-based-advance-and-management-of-adverse-events-of-immunotherapy-for-cancer

Research on cancer metabolism and novel therapeutic development (IND enabling efficacy, safety, and toxicology studies) Project management and coordination with CROs Medical writing and Grant writing Clinical Trial Coordination Patient communication and coordination (HIPAA certified)

Topic Editor: “Resistance to Immunotherapy: A Challenge of Cancer Treatment”; Journal of oncology. Impact Factor: 3.55 https://www.hindawi.com/journals/jo/si/708536/cfp/

• Responsible for creating, optimizing, and performing the On-Bead Two-Color (OBTC) Cell Screen for direct identification of highly selective cell surface receptor targeting peptoid compounds • Worked on the mechanistic study of the epigenetic modulating small molecule (TET2 activator) in cancer cells • Worked on the production and purification of His-tagged recombinant EZH2 protein • Responsible for xenograft mouse model and drug efficacy in vivo assays • Responsible for in depth data analysis, interpretation, and presentation for genomic, epigenomic, and transcriptomic data (RNA sequencing and ChIP sequencing data) • Generated data summaries for potential publication using common data analysis software • Responsible for the performing and training of graduate students on the design, development, optimization, and performance of various molecular biological techniques (e.g. western blotting, ELISA, molecular cloning, CRISPR, etc.) • Responsible for addressing methodological problems in experimental protocols and results • Engaged in the writing of manuscripts and grants

• Worked on the mechanistic study of modulating PDGFR signaling and protein translation initiation in Glioblastoma • Established primary cell cultures; maintained and used genetically engineered cell cultures and immortalized human cell lines for genetic and molecular analyses • Performed routine transgenic mouse colony breeding, genotyping, and maintenance • Responsible for performing the design, development, optimization, and performance of various molecular biological techniques (e.g. western blotting, qPCR, molecular cloning, flow cytometry, etc.) based on the requirement of research projects • Responsible for in depth data analysis, interpretation, and presentation for large scale proteomics/phosphor-proteomics data • Established signaling pathway maps with extensive details using Cell Designer software • Performed visualization of gene/protein interactions using Cytoscape software • Performed isolation of exosomes from cell cultures; extraction and quantification (qPCR) of miRNAs from exosomes • Engaged in the writing of manuscripts and grants

• Worked on the mechanistic study of modulating PDGFR signaling and protein translation initiation in Glioblastoma • Established primary cell cultures; maintained and used genetically engineered cell cultures and immortalized human cell lines for genetic and molecular analyses • Performed routine transgenic mouse colony breeding, genotyping, and maintenance • Responsible for performing the design, development, optimization, and performance of various molecular biological techniques (e.g. western blotting, qPCR, molecular cloning, flow cytometry, etc.) based on the requirement of research projects • Responsible for in depth data analysis, interpretation, and presentation for large scale proteomics/phosphor-proteomics data • Established signaling pathway maps with extensive details using Cell Designer software • Performed visualization of gene/protein interactions using Cytoscape software • Performed isolation of exosomes from cell cultures; extraction and quantification (qPCR) of miRNAs from exosomes • Engaged in the writing of manuscripts and grants

• Worked on the mechanistic study of small molecule cancer stem cell inhibitor and traditional Chinese medicinal drugs for the use in neuroblastoma, brain cancer, and pancreatic cancer • Worked on the identification of novel treatments for Alzheimer's disease (AD) • Performed experiments for validation of novel biomarkers (e.g. new biomarker panel for glioblastoma) for cancer diagnosis and better understanding of cancer progression • Established and used genetically engineered cell cultures and immortalized human cell lines for genetic and molecular analyses • Responsible for performing the design, development, optimization, and performance of various molecular biological techniques (e.g. western blotting, ELISA, molecular cloning, CRISPR, etc.) based on the requirement of research projects • Responsible for training of graduate students, visiting scholars, and summer students • Responsible for in depth data analysis, interpretation, and presentation for established genomic databases • Engaged in the writing of manuscripts and grants

• Teaching assistant for the course “Pharmacogenomics” and taught the “Methodologies and Applied Bioinformatics” part of the course, (1 semester); course “Chemotherapeutic/Infectious Disease Pharmacodynamics” (4 semesters); course “Principles of Pharmacokinetics and Pharmacodynamics” (1 semester)

• Worked on the mechanistic study of small molecule cancer stem cell inhibitor and the identification of its drug binding targets using enzymatic methods and proteomics • Evaluated the use of traditional Chinese medicinal drugs for the treatment of neuroblastoma, brain cancer, and pancreatic cancer using molecular biological techniques • Worked on the identification of novel treatments for Alzheimer's disease (AD) • Evaluated the TDP-43(A315T) mutation as a quick diagnostic biomarker for neurodegenerative disease and examined the mechanisms for TDP43 induced neuronal toxicity • Examined the roles of signaling pathways (e.g. PDGFR, EGFR, PI3K/ERK signaling) in the pathological process and treatment of cancer • Worked on the identification of the new applications of a few drugs in cancers, such as Docosahexaenoic Acid (DHA), Vitamin D, salinomycin, and thalidomide • Established and used genetically engineered cell cultures and immortalized human cell lines for genetic and molecular analyses • Analyzed cancer cells based on cell surface markers (CD133, CD34, c-kit, etc.) for cell separation and characterization using flow cytometry • Responsible for performing the design, development, optimization, and performance of various molecular biological techniques (e.g. western blotting, ELISA, molecular cloning, CRISPR, etc.) based on the requirement of research projects • Responsible for training of graduate students and summer students • Responsible for in depth data analysis, interpretation, and presentation for internal meetings and national conferences • Responsible for the maintenance of the Flow cytometry machine, and the training for fellow students for the use of flow cytometer. • Engaged in the writing of manuscripts and grants

Attended the prevention and control work of some diseases, such as AIDS and Hand-foot-mouth disease; Studied the operation of certain software, especially China Information System for Diseases Control and Prevention; Visited some hospitals, patients and schools to take part in works as disease diagnoses, medicine analysis and care of patients.