Shihyun You

Executive Director at GSK @ GSK

About

Specialties: Positive strand RNA viruses (hepatitis C virus, flaviviruses. alphaviruses, enteroviruses), negative strand RNA viruses (RSV, influenza virus), Hepatitis B virus Design a high throughput screen for drug discovery against a live virus. Investigate host innate immune responses against viral infection. Investigate host factors for viruses Target identification of a small molecule inhibitor. Identification/characterization of resistant mutations during drug treatment. Cell free replication/reporter system. RNA biology : Viral RNA structure, RNA-protein interaction, microRNA, siRNA screen

Country

United States

City

Collegeville

Industry

Pharmaceuticals

Skill

HCV, Drug Discovery, Viruses, HTS, Target Identification, Molecular Biology, qPCR, High Throughput Screening, Assay Development, Cell, Biochemistry, Cell Biology, Cell Culture, Lead Change, Life Sciences, Drug Development, Pharmaceutical Industry

Experience

Executive Director

GSK

2023-5 - Present · 3 yrs 5 mos

Upper Providence, Pennsylvania, United States

Leading HBV research and supporting HBV clinical programs and strategy

Senior Scientific Director

GSK

2020-5 - 2023-5 · 3 yrs 1 mo

Upper Providence Township, Pennsylvania, United States

Leading HBV discovery and strategy

Scientific Director

GSK

2017-11 - 2020-4 · 2 yrs 6 mos

Upper Providence, PA

Leading HBV Discovery

Chief Scientist/ Group Leader

GSK

2013-11 - 2017-10 · 4 yrs

RTP, NC

Liver Unit Group Leader of HBV drug discovery. Leading preclinical discovery programs for HBV functional cure. Antiviral DPU Drug discovery for respiratory viral infections Co-program leader of a lead op host lipid kinase program Program leader for host factors for respiratory viruses

Investigator (HCV and Antiviral DPU)

GSK

2009-9 - 2013-10 · 4 yrs 2 mos

Program leader for HCV HTS . Biology leader of a lead optimization anti-HCV program Co-program leader of a lead op host lipid kinase program

Principal Scientist (HCV DPU)

GSK

2008-10 - 2009-9 · 1 yr

Established an HCV reporter system for a high-throughput screen. Led an HCV drug discovery HTS program involving multi-disciplinary teams. Due-diligence of various external assets.

Research Associate

Rockefeller University

2007-1 - 2008-10 · 1 yr 10 mos

Charlie Rice lab

Involvement of the microRNA machinery in innate immunity using HCV and Sindbis virus. Investigation of the host antiviral response and Sindbis virus replication by live cell imaging. Understanding of the antiviral activity of an ISG using an RNA tagging approach.

Post Doc

The Rockefeller University

2001-1 - 2006-12 · 6 yrs

Charlie Rice lab

Identification/characterization of an RNA element in the coding region of the HCV genome. Biochemical mapping of RNA structure. Affinity pull down of RNA binding factors and characterization of the hits by siRNA. Ectopic expression of miR122 in non-liver cells.

Education

University of Kansas Medical Center

Biochemistry and Molecular Biology

1995 - 2000 · 5 yrs

Advisor: Dr. R. Padmanabhan Establishment of cell free replication assay system of Dengue virus 2. Identification of the cyclization sequence as a crucial replication element for Dengue virus.