Seunghee Cho
Chief Executive Officer
About
Based on AI deep learning algorithm, AAVATAR Therapeutics provides diagnoses system with each individual's disease, design and develops optimal gene therapy products according to the disease. The nanoparticle based products we make reflect the design of therapeutic agents based on a variety of individual gene mutations. To create precise and affordable drugs, our team is made up of passionate mathematicians, materials scientist, medicinal chemist, cell biologists, X-ray crystallographers and computer scientists. As a result, we aim for one stop service from design to production of gene therapy. By providing one stop service, it is expected for us to play a key role in the medical industry in the future. The following five technologies are the core of our artificial intelligence-based gene therapy technology. * 5 pillars of AI based platform in AAVATAR Therapeutics - Rare disease diagnosis system via multiomics - Rational drug design system (e.g. Nano-lense, Lipid nanoparticle, Chemically defined polymer, AAV) - In silico cellular status induction prediction system for cell engineering - In silico prediction for evasion of Immune system - In silico cell type specific surface marker / antibody development system * The strength of our team - Diagnosis of over 3000 diseases is quickly and accurately diagnosed by artificial intelligence according to 28 rules. - Various cutting edge vehicle technologies that transport therapeutic genes to the human body. (Self-assembly peptide, AAV, Nano lense, etc.) - Mass production system for gene therapy products. - Exact, rapid diagnosis and process development designed by DEO (Design of Experiment). - One-stop service from disease diagnosis to treatment production
South Korea
Seoul Incheon Metropolitan Area
Biotechnology
Upstream Processing, Downstream Processing, Qaulity Assessment, PCR, HPLC, UV/Vis, qPCR, Protein Purification, Western Blotting, Flow Cytometry, Molecular biology , X-ray crystallography, Circular Dichroism, Surface Plasmon Resonance, DLS, Isothermal Titration Calorimetry, Anaerobic Microbiology, Agarose Gel Electrophoresis, Silver Staining, ddPCR
Experience
Chief Executive Officer
AAVATAR Therapeutics
Seoul Incheon Metropolitan Area
Process Development Upstream and Downstream Lead
NeuracleGenetics
Seongbuk-gu, Seoul, Korea
* Upstream - AAV production optimization with bioreactor under various conditions based on DOE using statistics * Downstream - AAV purification optimization for column chromatography (affinity, ion exchange, HIC, SEC or multi-modal methods) and ultra-centrifugation * Quality assessment - Development of analytical methods and its applications for AAV characterization (Silver staining, ddPCR, EM, ELISA, HCP detection, Host cell DNA quantification, LPS detection, CMC-535, mycoplasma detection) * Manage the team over whole processes of AAV manufacturing
Senior Principal Scientist
Sunkyunkwan University
Suwon, Gyeonggi-do, Korea
* Z DNA-Zalpha protein characterization and mechanism study * Structural study of PDK4 – chemical complex * Structural and mechanistic studies of cyanuric acid hydrolase and commercial application
Senior Researcher
NOUL Co., Ltd.
Yongin, Gyeonggi-do, Korea
* Lab on a chip module development applied in malaria, AIDS, and TB diagnosis
Postdoctoral Research Associate
Biotechnology Institute at the University of Minnesota
Greater Minneapolis-St. Paul Area
* Metagenomic analysis of different parts of the colonoscope liners * Developing screening method for identifying bacterium that convert primary bile acid to secondary bile acid
Graduate Research and Teaching Assistant
University of Minnesota
Greater Minneapolis-St. Paul Area
* Structure, mechanism and commercial application of cyanuric acid hydrolase * Biodegradation of s-triazine * Protein engineering by rational and random mutagenesis approaches
Research Scholar
University of Washington
Greater Seattle Area
* Structural study between COP9 and Cullin E3 ligase to understand general regulation mechanism of cullin E3 ligase * Structure and behavior study of disease related mutant type of alpha B crystalline with NMR spectroscopy
Graduate Student Research Assistant
Sungkyunkwan University
Suwon, Gyeonggi-do, Korea
* Structural and biochemical characterization of small heat shock protein 20.8
Research Scientist (Samsung Biomedical Research Center)
SBC
Suwon, Gyeonggi-do, Korea
* Structural studies and biophysical characterization of Arc protein
Undergraduate Research Assistant
Pohang Accelerator Laboratory
Pohang, Gyeongsangbuk-do, Korea
* Research scientist
Education
University of Minnesota
Chemical process engineering, Biodegradation of s-triazine, enzyme mechanism study
Structure, mechanism and commercial application of cyanuric acid hydrolase and biodegradation of s-triazine
Sungkyunkwan University
X-ray crystallography
Structural and Biochemical Characterization of small heat shock protein 20.8
Handong Global University
Biological science, Computer science and Food engineering
Seunghee Cho's Contact Information
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