Sarah Wortman

Substitute Teacher for the Twin Rivers Unified School District. Substitute teaching in primary and secondary education as well as in general education and special education.

Science teacher at the School of Engineering and Sciences, teaching 8th grade science and 11th grade chemistry. Completed pre-induction program

Substitute teacher for the Sacramento City Unified School District. Substitute teacher at Tahoe Elementary for two weeks of 2024-2025 school year in a general education 3rd grade classroom. Lesson planned. Substitute teacher at Washington Elementary for 2023-2024 school year. Experience working in special ed and general ed classrooms. Experience working along side teacher as well as independently in the classroom.

Designed and prepared formulations in support of preclinical studies. Provided guidance and recommendations to project teams to reach milestones. Collaborated with external partners. Authored and reviewed reports.

Preclinical - Supported multiple preclinical programs, while working on multi-functional teams. Activities included physicochemical characterization of lead compounds and vehicle selection for in vivo testing and toxicology studies based on compound(s) solubility, stability and bioperformance. Increased in-house capabilities with new formulation techniques and equipment. Clinical - Supported projects at Phase I and Phase III. Activities included preparing preformulation package, tablet formulation development for Phase I, and preparation of GMP batches at CRO for Phase I clinical trials. Additional experience in DoE and powder characterization. Co-inventor of GS-9716

Preclinical - Experience working on multi-functional teams as lead pharmaceutics representative on discovery projects. Experience in physicochemical characterization of small molecules. Techniques include DSC, TGA, TG/MS, XRPD, DVS/VTI, SEM, solubility, pKa, LogP, hot-stage microscopy, particle size distribution, solid-state stability, photolytic stability, solution stability, HPLC, Raman. Experience in form/salt screening and form selection. Experience in formulation of small molecules. Techniques include solubilizing solutions, suspensions, microsuspensions, PLGA microspheres, PLA nanospheres, and self-emulsifying drug delivery systems. Experience in solid form and salt screening. Co-inventor of AMG232.

Formulation - Experience in direct compressed tableting, film coating, DoE and characterization of powder blends. Experience writing batch records and excipient specifications.

Preformulation - Physicochemical characterization and formulation of small molecules and peptides. Experience in PLGA microspheres utilizing W/O/W emulsion for the sustained release of a peptide.