sanne hensen

This research was focused on the detection of citrullinated fibrinogen specific antibody secreting B cells in patients suffering from rheumatoid arthritis.

We studied two protein subunits of the RNase MRP complex, an RNA-protein complex involved in cartilage hair hypoplasia, an autosomal recessive disorder resulting in dwarfism, brittle hair and T-cell deficiency.

Xenopus laevis, the African clawed frog, was used as an in vivo model system for ageing-related protein folding diseases.

Selection of monoclonal antibodies by phage display - Generation of antibody libraries for phage display

Subject: Detection of peptidylarginine deiminases and protein citrullination Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation of the synovial joints, which can eventually result in joint destruction. RA patients frequently produce autoantibodies against citrullinated proteins, proteins in which an arginine residue is converted into a citrulline by peptidylarginine deiminase. The project focused on the development of new methods for the detection of citrullinated proteins. - Member of the board meeting of the Department of Biomolecular Chemistry representing the PhD students and post-docs - Guidance of internships of 2 Molecular Life Sciences students (8 weeks and 9 months) - Organization of the practical course “Project Biochemistry” for first year Chemistry, Molecular Life Sciences and Natural Sciences students

* Thesis title: “The heat is on. HSF1 integrates cellular stress response pathways.” Supervised by Prof. N.H. Lubsen * Member of the board meeting of the Department of Biomolecular Chemistry representing the PhD students and post-docs * Guidance of internships of 2 Biology students (10 weeks and 7 months) * Organization of a Technical Forum for 160 PhD students: “How to design your PhD thesis” * Organization and guidance of the practical course “Molecular Biology” for first year Biology students

Assistant practical course “Project Biochemistry” for first year students Chemistry, Molecular Life Sciences and Natural Sciences - Member of the organizing committee of a studytour to China