Sang Soo Kim
Principal Scientist @ Kaigene, Inc
About
Biomedical researcher with over 18 years of experience spanning academia and industry. Applying nanotechnology to address unmet medical needs in treatment of cancer, neurological disorders, and infectious diseases. Proven track record in conceptualizing and executing therapeutic strategies with direct translational relevance. Led efforts in tumor-targeted and immune-targeted nanomedicine including non-viral nanodelivery systems for small molecules and nucleic acid therapeutics (mRNA, siRNA/miRNA, lnRNA, ASO, and pDNA). Specialized in nanoparticle delivery across the blood-brain barrier for CNS diseases and malignant brain tumors. Authored 60+ publications, reviews, and book chapters in areas including cancer therapy, gene delivery, immunoliposomes, targeted drug delivery, biomaterials, tissue engineering, and regenerative medicine. Expertise in molecular biology, biotechnology, cancer and stem cell biology, biomaterials, and translational preclinical research.
United States
Potomac
Biotechnology
Brain Tumors, CNS disorders, Targeted Drug Delivery, Nanomedicine, Cancer Immunotherapy, siRNA, Gene Delivery, Nanobiotechnology, Cancer Research, Gene Therapy, Translational Medicine, Pharmaceutical Formulation, Animal Models, Tumor Immunology, Transcriptomics, Cancer Stem Cells, Nanoparticles, Translational Science, Neuroscience, Nanotechnology
Experience
Principal Scientist
Kaigene, Inc
Washington DC-Baltimore Area
Director
SynerGene Therapeutics
Washington DC-Baltimore Area
Oversee development of novel nanomedicines and in vivo preclinical/efficacy studies - Novel tumor-suppressor gene therapy development - Immune checkpoint inhibitor / pre-IND studies - Develop medical countermeasure against biological threat agents (nerve agent) - Develop broad spectrum antiviral nanomedicines
Adjunct Assistant Professor
Georgetown University Medical Center
Washington DC-Baltimore Area
Lead and manage early discovery of advanced nanomedicine for cancer therapy - Develop small molecule-based therapeutics against pediatric brain cancer - Investigate nanomedicines enhancing anti-cancer immunotherapies and radio-sensitization Develop immunoliposome-based nanoparticles for CNS drug delivery - SNCA ASO-based nanomedicine for treatment of neurodegenerative CNS diseases (Parkinson’s disease) - Nanoparticle delivery of CRISPR/Cas9 for genome editing Develop mRNA-based vaccine nanoparticles
Assistant Professor
Georgetown University Medical Center
Washington DC-Baltimore Area
Develop nanomedicines reversing resistance to checkpoint inhibitors Develop immunoliposome-based nanoparticles for CNS drug delivery - SOD1 ASO-based nanomedicine for treatment of neurodegenerative CNS diseases (ALS) - Nanotherapeutics preventing neuronal apoptosis following fatal neuroinflammation of brain
Instructor
Georgetown University Medical Center
Washington DC-Baltimore Area
Develop immunoliposome-based nanoparticles for CNS malignancy - Tumor suppressor gene therapy against adult brain tumors (Glioblastoma) - Brain-tumor targeted delivery system of chemotherapeutics with enhanced anti-tumor efficacy and reduced side effects
Postdoctoral Fellow
Georgetown University Medical Center
Washington DC-Baltimore Area
Develop tumor-targeted drug delivery system for cancer therapy - Studied nano-delivery system targeting cancer stem cells and nanomedicine reversing chemo-resistance - Immunoliposome-based nanoparticles to deliver iron oxide nanoparticles for enhanced cancer diagnostics and therapeutics
Postdoctoral Fellow
Texas Tech University Health Sciences Center El Paso
El Paso, Texas, United States
Studied brain-targeted siRNA delivery system for treatment of neurotropic flavivirus (Dengue and West Nile viruses)
Postdoctoral Fellow
Harvard Medical School
Boston, Massachusetts, United States
Research focused on materializing RNAi-based therapy of HIV infection - Developed humanized mice with a functional human immune system for preclinical study of viral infections - Developed T cell-specific siRNA delivery system for treatment of HIV infection
Education
Seoul National University
Biochemical Engineering and Biotechnology
Research focused on tissue engineering and regenerative medicine - Fabricated implantable three-dimensional polymer scaffolds for tissue engineering - Applied stem cells in regeneration medicine - Studied gene and protein delivery for enhanced tissue regeneration
Seoul National University
Biochemical Engineering and Biotechnology
Optimized production of avermectin, a natural product with exceptional insecticidal activity, using genetic engineering
Seoul National University
Chemical Engineering
Sang Soo Kim's Contact Information
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