Sampat Ingale
Senior Director of Peptide and Protein Chemistry @ Biohaven
About
Accomplished scientist with background in developing peptide based therapeutics, antibody-drug conjugation(ADC), antibody-oligonucleotide conjugation (AOC), and protein-peptide/glycopeptide conjugation. Discovered novel and proprietary site-specific conjugation method to improve ADC design. Experienced in development of lipid nanoparticle (LNP) platform. Specialties: Process development, Antibody-drug Conjugation, Peptide Synthesis, Synthetic vaccines, Chemo-enzymatic synthesis, targeted LNP, Project management, Peptide medicinal chemistry
United States
Greater Boston
Pharmaceuticals
Conflict Resolution, Chemical Biology, Biotherapeutics, CRO Management, Cancer Research, Data Analysis, Drug Design, Program Management, ASO, Process Optimization (Manufacturing), Oligonucleotide Synthesis, Bioconjugation, Affinity Chromatography, Cross-functional Team Leadership, Antibody drug conjugation, Analytical Skills, Publications, Small Molecules, Organic Chemistry, Nuclear Magnetic Resonance (NMR)
Experience
Senior Director of Peptide and Protein Chemistry
Biohaven
Cambridge, MA
Director of Peptide Chemistry
Biohaven
Cambridge, Massachusetts, United States
Director of Chemistry
Flagship Pioneering
Cambridge, Massachusetts, United States
- Explored strategies for lipid nanoparticle decoration with various ligand for active targeting of immune cells and extrahepatic delivery
Principal Scientist- Bioconjugation and Peptide Chemsitry
Merck
Cambridge, Massachusetts
- Developed site-specific conjugation method to improve ADC design by glycoengineering Fc glycan - Peptide mRNA display platform - Presentation of antigens (Carrier protein, Lipid Nanoparticle, Virus-like Particle (VLPs) - Synthetic peptide based antigen design and evaluation
Associate Principal Scientist-Bioconjugation and Peptide Chemistry
Merck
Bioconjugation capability build at Cambridge site – Led and assembled group (recruit, capital investment) – Synthesize, purify and characterize diverse therapeutic modalities including peptides, macrocyclic peptides, peptide-peptide bicyclic molecules, ADCs, peptide/glycan-carrier protein conjugates - Established workflow for synthesis, analysis and purification of small and large molecules (HIC, IEX, RP-HPLC, LC-MS, SEC-MALS, CE-SDS, NMR, AKTA) – Developed processes for enzymatic (sortase) and chemical (engineered cysteine) for site-specific conjugation - Characterization and design of drug-linker payloads for new ADCs development
Senior Research Scientist - Protein and Peptide Chemistry
Novo Nordisk
Seattle, Washington
• Structure activity relationships for peptides targeting obesity
Scientist
Sorrento Therapeutics, Inc.
Greater San Diego Area
- Antibody Oligonucleotide Conjugation (random lysine, cys) - Purification of conjugates (Protein A, HIC, Size exclusion)
Research Associate
Scripps Research
La Jolla, CA
Senior Manager-Global Discovery
Takeda
Andheri, Mumbai, India
• Facilitated various global discovery projects to achieve decision gate milestones by monitoring and allocating resources for multi-step, small molecule synthesis • Supervised centralized purification and analysis group: compound purification (HPLC), characterization and identification (LC-MS/NMR/GC), method development and modernized incoming and outgoing sample flow
Research Associate
Scripps Research
La Jolla, CA
1) Ingale, S.; Dawson, P.E. On Resin Side-Chain Cyclization of Complex Peptides Using CuAAC. Org. Lett. 2011, 16, 716-722 2) Ingale, S.; Gach, J.S.; Zwick, M.B. Dawson, P.E. Synthesis and Analysis of the Membrane Proximal External Region (MPER) Epitopes of HIV-1. J. Pept. Sci. 2010, 16, 716-722
Research and Development Officer
Unilever
Andheri, Mumbai, India
Development of oral care formulations
Education
The University of Georgia
Organic chemistry
Carbohydrate based cancer vaccine
University of Mumbai
Chemistry
Sampat Ingale's Contact Information
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