Young Lee
Principal Scientist/Group Leader, Biologics and Process R&D @ Merck
About
At Merck, my role as Principal Scientist in Cell Line Development for early- and late-phase projects marks a key chapter in advancing biopharmaceuticals. Our team's expertise in cell culture and molecular biology is pivotal in pioneering treatments that promise a healthier future. Reflecting on a rich tenure at Johnson & Johnson, we championed first-in-human research, harnessing protein expression techniques to lay foundations for revolutionary medical breakthroughs. This journey is characterized by an unwavering commitment to excellence and a strategic vision that continues to guide my efforts in the field.
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United States
Pharmaceuticals
Leadership, Cell Engineering, Synthetic Biology, Mammalian, Protein Expression, Molecular Biology, Research, Cell Culture, Technical Reports
Experience
Principal Scientist/Group Leader, Biologics and Process R&D
Merck
Rahway, New Jersey, United States
🧪 Lead a team of scientists working on FIH and late-phase biologics programs 🧬 Drive cell line development for monoclonal antibodies (mAbs), non-mAbs, and complex biologics 📊 Oversee stability studies, including pre-LIVCA and LIVCA assessments, to ensure robust cell line performance 📝 Author and review regulatory documents (INDs, BLAs) for global health authority submissions 🏭 Serve as a technical SME for MCB/WCB manufacturing, ensuring compliance with regulatory and quality standards 🤝 Collaborate cross-functionally with PD, analytical, regCMC, and QA teams to support program advancement
Scientist/Team Leader, Cell Line Dev
Johnson & Johnson Innovative Medicine
Spring House, Pennsylvania, United States
Scientific Investigator, Process Dev
GSK
King of Prussia, Pennsylvania, United States
Education
Washington University in St. Louis
Energy, Environmental, and Chemical Engineering
🔬 Developed a programmable and reversible gene regulation system during my PhD 🧬 Combined CRISPR interference (CRISPRi) with antisense RNA (asRNA) for dual-level control ⚙️ Used CRISPR-Cas9 to repress specific gene expression via targeted DNA binding 🔁 Employed asRNA to bind the CRISPR guide RNA (sgRNA), restoring gene activity 💡 Enabled dynamic and flexible gene control, useful for genetic and synthetic biology applications
Brandeis University
Biology, General
Young Lee's Contact Information
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