Roopa Payanur Sripathi

* Senior analyst/ researcher and lead content reviewer for somatic cancer database- serving both domestic and international clients. * Review and perform somatic variant curation analysis that captures functional, clinical/ preclinical and prognostic evidence of somatic variants in solid/ hematological cancers.

* As a senior Scientist I reviewed clinical reports generated by interpretation and analysis of sequenced cancer patient samples using a proprietary NGS platform/ tool. • Developed content and analysis, aiding international clients to enrich their in-house scientific databases. • Derived biological significance of the results obtained from NGS and created reports to derive key insights from a patient’s genome. • Proficient in using NGS data analysis tool. • Liaised with leading hospitals and oncologists to highlight the importance of NGS analysis and clinical utility of somatic variants mentioned in patient reports.

* Awarded Graduate Fellowship for Ph.D that culminated in Masters in Biomedical Sciences * Cleared qualifying examination for Ph.D study * Graduate research focusing on studying the mechanism of macrophage phenotype regulation by MicroRNAs * Extensive analysis of miRNAs, which might be one of the key molecules controlling M1 to M2-like macrophage phenotypic switches * Identified and validated miRNA targeted genes * Responsible for the presentation of technical posters at Graduate Student Days and Association meets * Publication: Shukla S, Levine C, Sripathi RP, Elson G, Lutz CS, Leibovich SJ. The Kat in the HAT, Mediators Inflamm. 2018;2018:7852742, Published 2018 Jun 6, doi:10.1155/2018/7852742

As a Junior Manager in the Biologics Intellectual Property Unit * I Collaborated with business development team to analyze the Bio-similar product marketability and provided Freedom to Operate (FTO) reports with patent landscapes * Conducted prior-art searches, described biologic patent claims, analyzed scope of the claims and identified patent expiries in several global countries. • Proficient in using both paid and unpaid databases for patent analysis.

As a Junior Research Fellow in the Science Innovation & Predictive Diagnostics department * I designed unique primer pairs for PCR amplification of specific regions of genes associated with M.tb virulence • Conducted a sequence comparison study between clinical isolates and the lab virulent H37Rv strain and established human pathogen, CDC1551 to identify Single Nucleotide Polymorphisms (SNPs). • Identified about 30 SNPs out of 1200 genes from 200 different M. tb clinical isolates and delivered it to the Bioinformatics team for incorporation into a SNP database.

As a Summer Intern in the department of Molecular Biology * worked on target validation of essential genes of Mycobacterium tuberculosis using antisense mRNA technology * Validated the importance of essential genes in M.Smegmatis by anti-sense mRNA technology.