Reza Nejadnik

- Development of stable dosage forms for biopharmaceuticals - Formulation and characterization of novel therapeutic proteins and antibodies - Developability and device-ability evaluation of candidate molecules - Development and establishment of robust and scalable manufacturing processes for drug products intended for clinic and market - Representing the drug product function in global international project teams and support global work-streams on innovation and cross-site harmonization aspects - Tech transfer from and to CROs and to GMP teams - Analytical developments and preparation and revision of SOPs - Management and supervision of scientists and technicians

Member of the managing board and work package leader in COMPACT project (a European project under the framework of Innovative Medicines Initiative (IMI) comprising 11 academic and 12 industrial partners (including Abbvie, Boehringer Ingelheim, GlaxoSmithKline, Merck-Serono and Sanofi-Aventis) with a total budget of 30 million Euros: http://www.compact-research.org/). COMPACT stands for Collaboration on the Optimization of the Macromolecular Pharmaceutical Access to Cellular Targets

Project leader and research scientist, Leiden Academic Center for Drug Research (LACDR) - Academic leader of project on drug delivery systems for proteins and peptides. Areas of research: a) Development and characterization of a range of nano- and micro-structures for delivery of peptides and proteins including nanoparticle-loaded dissolving microneedles for interadermal delivery, b) Biophysical characterization and understanding of protein aggregation and protein-material interactions, c) Proteins at solid-liquid and air-liquid interfaces - Additional projects conducted on understanding of the risks of presence of protein aggregates in pharmaceuticals and drug delivery with degradable microspheres in partnership with industry (Novo Nordisk, FeyeCon and OctoPlus)

Postdoctoral researcher at professor John Jansen’s group, Department of Biomaterials, Faculty of Dentistry - Area of research: Development and characterization of novel soft materials (including hydrogels, colloidal gels and hydrated organic-inorganic structures) for application in hard tissue regeneration with a focus on organic-inorganic interface - Additional projects on enzyme assisted deposition of mineral calcium phosphates on surfaces and within hydrated matrices were performed

Visiting researcher at professor Philip Messersmith’s lab, Department of Biomedical Engineering - Area of research: Catechol groups for cross-linking of hydrogels and immobilization of macromolecules onto solid surfaces

Postdoctoral research scientist at professor Carlos Garcia’s lab, Department of Chemistry - Area of research: Protein adsorption to nano- materials and structures for biosensing applications. Particular attention was paid to maximizing the loading while preserving protein activity

Biomedical Engineering Department Promotors: Professor Henk Busscher, Professor Willem Norde and Professor Henny van der Mei Thesis: Polymer brush-coatings to prevent protein adsorption, bacterial adhesion and therewith biomaterial associated infection. Research covered investigating the formation of a physisorbed polymer brush-coating on hydrophobic surfaces, studying the conformation of hydrophilic polymer in the coating and studying the effect of the coating on bacterial adhesion, their adhesion force and subsequent growth.

PhD thesis: polymer brush coatings to prevent biomaterials associated infection; initial bacterial adhesion and biofilm formation.

Thesis: Role of glucosamine in inhibition of cartilage degradation