Reena Mehta

Leading enterprise-level transformation initiatives across R&D Clinical Operations and Supply Chain to optimise global study planning and delivery. Accountable for shaping and delivering six strategic transformation workstreams improving clinical study planning, operational efficiency, and cross-functional decision-making. Leading end-to-end process redesign across R&D Operations and Supply Chain to streamline clinical development workflows and reduce operational waste. Deploying centralised data-driven and AI-supported solutions to enhance planning quality, accelerate delivery timelines, and strengthen portfolio decision making. Driving collaboration across global clinical operations, supply chain, digital, and data science teams to embed scalable solutions across the organisation. Influencing senior leadership and governance forums to align transformation initiatives with broader R&D strategy

Strategic and operational leadership for late-stage global clinical programs targeting SLE and Lupus Nephritis. Providing global clinical operations leadership for a Type 1 interferon inhibitor program in preparation for regulatory registration. Leading cross-functional teams to ensure delivery of complex global studies on time, within budget, and to quality standards. Optimised study enrolment across the portfolio within three months by initiating targeted operational improvement workstreams. Driving development of clinical submission strategy and data packages to support regulatory filings. Acting as a key interface between clinical development, regulatory, medical, and operational teams to ensure successful program delivery.

Led the global clinical development strategy for an adenoviral immunotherapy targeting Chronic Hepatitis B. Directed the clinical development strategy and execution for the HBV immunotherapy program through early- and mid-stage development. Rebuilt the Clinical Development Plan and Therapeutic Product Profile, enabling a clearer pathway toward potential BLA registration. Designed a strategic program playbook for executive leadership, improving alignment across R&D, commercial, and corporate stakeholders. Led and expanded the clinical operations team, providing line management and mentorship to study managers and clinical trial staff. Oversaw delivery of multiple clinical studies while navigating operational challenges and accelerating program progress. Contributed to IND packages, scientific publications, and conference presentations.

Global operational leadership for multi-country vaccine and infectious disease clinical programs. Directed global Phase II–III clinical trials across vaccines and infectious diseases including Influenza, RSV, Human Metapneumovirus, and SARS-CoV-2. Led complex global study delivery across multiple regions while managing CROs, vendors, and cross-functional stakeholders. Ensured trials were delivered on time, within budget, and compliant with global regulatory requirements. Provided operational strategy to accelerate study timelines and mitigate risks across the clinical portfolio.

Led global development planning for investigational molecular entities and medical devices across Phases 0–IV within Immunology and Respiratory. Partnered with clinical, regulatory, and commercial teams to shape integrated development strategies. Coordinated global program execution across multidisciplinary teams and external partners.

Helped establish a new Early Clinical Pharmacology Operations Department within the UK organisation. Delivered Phase I–IIa clinical pharmacology studies supporting early development programs. Built operational frameworks to support efficient execution of early phase clinical trials.

Managed Phase I–IIa clinical pharmacology studies within respiratory diseases including asthma and COPD. Supported early clinical development strategy and study execution within Discovery Medicine.

Gained hands on experience as an Early Development Study Team Leader and Clinical Study Monitor