Ramin Pajoumshariati

• Provide executive scientific leadership for a multidisciplinary R&D organization advancing therapeutic proteins, regenerative biomaterials, and tissue-engineered platforms from concept through preclinical readiness. • Define and execute long-range innovation strategy, building a diversified pipeline of translational technologies while aligning scientific priorities with corporate growth objectives. • Lead the development of multiple first-in-class biomedical platforms spanning drug delivery systems, advanced biomaterials, and soft-tissue regeneration constructs — positioning the organization at the forefront of next-generation therapeutic solutions. • Architect scalable manufacturing capabilities, including the establishment of GMP-aligned collagen production, enabling reliable supply of clinical-grade biomaterials for implantable and regenerative applications. • Oversee end-to-end research execution across cell line development, biomaterials engineering, assay development, and preclinical translation, ensuring technical rigor, reproducibility, and regulatory readiness. • Build and mentor high-performing scientific teams while fostering a culture of innovation, accountability, and operational excellence. • Establish strategic collaborations with academic institutions, industry partners, and regulatory stakeholders to accelerate translational outcomes and strengthen competitive positioning. • Implement structured project governance, resource planning, and milestone management to deliver complex programs on schedule and within budget. • Serve as a key scientific advisor to executive leadership and investors, articulating technology strategy, development risk, and commercialization pathways. • Spearhead platform technologies with significant commercialization potential, supporting future venture creation and strategic expansion initiatives.

• Developed new cell lines for regenerative and investigative studies, leading protein production efforts. • Led tissue engineering projects for cartilage, tendon, and ligament, achieving advancements in tissue regeneration. • Optimized assays for evaluating tissue-engineered products and designed MAT, endotoxin, and BMP2 activity assays.

• Developed a method for differentiating hiPSCs towards mature podocytes, leading to advancements in organ-chip technology. • Invented a tri-culture glomerulus chip with hiPSC-derived podocytes, endothelial cells, and mesangial cells. • Successfully incorporated hydrogel-based matrix into organ-chips for 3D vascular-stromal compartment.

• Developed a microfluidic-based approach for encapsulating organoids and cells in microgels using non-fluorinated oils • Designed and fabricated a 3D gut-on-a-chip device for co-culture of multiple cells • Invented a new polymer (PBSGL) for guided bone regeneration and evaluated in vitro and in vivo for periodontal application

• Developed photo-crosslinkable cartilage-derived and keratin matrices for tissue engineering projects. • Evaluated the effect of physicomechanical and niche growth factors on zonal differentiation of mesenchymal stem cells. • Assisted in grant and proposal writing for organizations like NIH, NSF, and DOD.

• Developed bioreactors for plant cell cultures and designed drug delivery systems for anticancer drugs. • Improved tissue engineering scaffolds using medicinal plants and supervised graduate and undergraduate students. • Managed projects on extracting bioactive compounds from medicinal plants at Medicinal Plants & Drugs Research Institute, SBU.

• Founded and equipped the Tissue Engineering and Stem Cell Laboratory at Sharif University of Technology. • Advised two master's students and managed biotechnology projects and a cell culture lab. • Successfully wrote and obtained a national grant of $100,000 for research in the field.

ᵒ Taught: mathematical modeling, unit operation II, and HYSYS (a modeling software) for chemical engineering

ᵒ Taught principles of water and wastewater treatment (M.Sc. course) and HYSYS (a modeling software) for chemical engineering

• Designed and produced three fully automated membrane sequencing batch reactors (MSBRs) to optimize biological treatment processes. • Obtained a grant from the Iranian national oil company for treatment of petroleum wastewater using MSBRs. • Achieved the first rank Ph.D. student among all chemical engineering fields.

ᵒ Served as both senior scientist and product manager for tissue engineering skin products ᵒ ᵒ Managed several projects and products including collagen, development of new commercial media for keratinocytes, and bilayered skin products. ᵒ ᵒ Managed reagent and biological product lines ᵒ ᵒ Worked in cross functional teams, both local and remote, with demonstrated ability to communicate product strategy, driving stakeholders to shared vision and goals. ᵒ Fabricated the bilayared skin equivalent ᵒ ᵒ Isolated keratinocyte and fibroblast cells from human foreskin ᵒ ᵒ Fabricated various types of biodegradable and biocompatible scaffolds ᵒ ᵒ Evaluated the biocompatibility of polymers ᵒ ᵒ Developed and formulated several culture mediums for keratinocyte cells ᵒ ᵒ Designed and produced a bench-scale bioreactor (perfusion) for the fabrication of a tissue-engineered skin ᵒ ᵒ Evaluated the regeneration of the skin using stem cells in the experimental animal burn ᵒ Produced and synthesized collagen type I from calfskin ᵒ Fabricated tissue-engineered gingiva and implanted in animal models (dogs) ᵒ Fabricated of polymeric membranes for the guided bone generation in periodontal applications

Ph.D. Dissertation: Membrane sequencing batch reactors: Characterization of membrane fouling and assessment of performance in biological treatment

M.Sc. thesis: Fabrication of bilayared skin equivalent

Thesis: Selecting industrial dryer type using Fuzzy Logic