
Pius Padayatti
Senior Scientist @ Confometrx, Inc
About
I am a protein biochemist interested in membrane proteins and their structure-function studies. My career started studying GPCRs and their characterization of receptor kinetics in Diabetes animal models. By characterizing adrenergic and serotonergic receptors in the brain I explored a critical role in regulating hormone status in disease animal models. This followed a highly productive post-doctoral period of learning X-ray crystallography, membrane protein crystallization, and structure-guided drug design techniques. Consequently, several years of working with major pharmaceutical companies, starting with Amgen, in GPCR structural biology projects led to gaining skills in drug discovery. In addition, I also worked in the Automation industry specializing in membrane protein crystallization robotics. I worked for a few years in academia with NIH funds to perform innovative science in membrane channel protein structure-function studies.A proven scientist, who works collaboratively and can lead projects. Focused Protein Biochemist who delivers consistent and professional work for every assignment. Offers 10+ years of experience in biotechnology industry environments and top-notch abilities in membrane and soluble protein engineering, expression, activity assays, assay development, Biophysical techniques, and more focus on Structural biology. I am trained in various aspects of all classes of proteins and membrane protein target-directed drug discovery in therapeutic applications. Diligent Scientist bringing advanced knowledge of protein chemistry, biophysical techniques, and all aspects of Structural Biology. Proven capabilities in research planning and management. Driven to continuous scientific exploration with a curious, analytical mindset. History of making significant advancements in knowledge and understanding of biological life. I am at a career stage and am looking to develop into a senior role in a pharmaceutical research environment. If a position needs a wide variety of skills in protein chemistry, please message me here. I will respond for sure. Thanks for visiting my profile. PubMed link: https://www.ncbi.nlm.nih.gov/pubmed/?term=padayattiGitHub page link: https://github.com/padayatti1
United States
San Marcos
Biotechnology
Machine Learning, DMPK, Antibody Engineering, Molecular Diagnostics, Python (Programming Language), Team Leadership, synchrotron data , membrane protein purificaiton, Mammalian Cell Culture, Research Support, Research Projects, Research Collaboration, Biophysical Chemistry, SPR, CD spectroscopy, folding assays , Diabete Mellitus, Small Animal Models, Membrane Proteins, Neuroscience
Experience

Sr. Scientist
San Diego, CA
Established the peptide sensor detection in the Roswell Biochips; decoded the data from the enzyme conformational changes recorded; contributed to establishing various assays using the peptide sensor chemically modified to various applications including binding assays, sequencing, CRISPER based assay ssytem

Staff Scientist
San Diego
Multi-complex mitochondrial membrane proteins crystallization and structure determination; Established LCP methods to drive large complex crystallization. Successfully established the crystal systems comprising the membrane domain and cytosolic domain (a2b crystals of holo TH enzyme) in LCP methods; regular synchrotron data collection and most familiarity with microcrystal data collection on microfocus beamlines (SSRL). XFEL projects in collaboration with Vadim Cherazov lab for microcrystal data collection. Membrane protein expression in insect cells and yeast cell fermentation. Establsiehd the crystal system for MsbA class of bacterial channel proteins and determined lipid bound structures of relevance to understand mechanism of the transport of lipids.
Education
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