Patrick Scheerer

Dr. rer. nat. Patrick Scheerer Research Group Leader (permanent) / Principal Investigator Charité - Universitätsmedizin Berlin (Charité University of Medicine Berlin) Campus Charite Mitte - CC2 - CCO Institute of Medical Physics and Biophysics Group Structural Biology of Cellular Signaling - AG Scheerer Protein X-ray Crystallography - Cryo-Electron Microscopy - Signal Transduction Charitéplatz 1 [Internal address: Virchowweg 6 / Building 2360] D-10117 Berlin, Germany Group website. https://biophysik.charite.de/forschung/ag_proteinstrukturanalyse_signaltransduktion/ Institute website. http://biophysik.charite.de/forschung/ University website. http://www.charite.de/ Teaching activities (Faculty of Medicine "Human Medicine") Lectureship - (Teaching performance 8 SWS per semester plus examinations)

Radiation Protection Manager Institute of Medical Physics and Biophysics

Institute of Medical Physics and Biophysics - AG Klaus Peter Hofmann Responsible scientist for Protein X-ray Crystallography Teaching activities (Faculty of Medicine "Human Medicine") Lectureship - (Teaching performance 4 SWS per semester)

Institute of Biochemistry - AG Krauß/Höhne Ph.D. student Teaching activities Humboldt-Universität zu Berlin - Faculty of Biology - Biophysics Supervisor/Tutor: Practical course "Protein X-ray Crystallography" - AG Höhne

Institute of Biochemistry - AG Wolfgang Höhne Trainee Diploma student

Collaborative Research Centre 1423 (SFB 1423) "Structural Dynamics of GPCR Activation and Signaling" 2024-2027 Second Period SFB 1423: Subprojects: A01 and A05 and Z03 “Structural Dynamics of GPCR Activation and Signaling” supported by the German Research Foundation (DFG) Cells communicate with each other and with their environment via receptors. The G protein-coupled receptors (GPCRs) are the largest group of membrane receptors and occur in almost all living organisms. In the Collaborative Research Centre 1423 „Structural Dynamics of GPCR Activation and Signaling„, scientists from the life sciences, medicine, pharmacy and bioinformatics of our university are investigating the interactions of GPCRs, the peptide receptors and the adhesion receptors, which have so far been little studied, together with their partners at the Charité – Universitätsmedizin Berlin, the Martin Luther University Halle-Wittenberg and the Heinrich-Heine University of Düsseldorf. The aim of this CRC initiative is to understand the structural dynamics of ligand binding, signal transduction, and downstream control of G protein- and arrestin-signaling pathways using native ligands as well as artificial probe molecules in conjunction with hybrid methods of structural biology including NMR, X-ray (conventional and serial protein X-ray crystallography at synchrotrons and free electron lasers), cryo-electron microscopy, mass spectrometry and computational methods (molecular modeling and dynamics). Phenomena such as biased signaling are tackled using assays that target specific signaling pathways. Results are tied in with a phylogenetic analysis of GPCRs, arrestins and G proteins. One goal of the CRC is to clarify the dynamic structural states of these GPCRs in order to understand their functions. This could lead to the development of novel therapeutics for this class of GPCRs.

ALLOstery in Drug Discovery - ALLODD - 2022-2025 (European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant) The ALLODD project is a collaboration between 13 academic and industrial organizations with 14 ESR/PhD positions available. The aim of ALLODD is to train a new generation of scientists to exploit the concept of allostery in drug design, putting together a whole array of technologies to identify and characterize allosteric modulators of protein function that will be applied to therapeutically relevant systems. https://www.allodd-itn.eu/

Collaborative Research Centre 1078 (SFB 1078) "Protonation Dynamics in Protein Function" 2021-2024 Third Period SFB 1078-B6 Full Project: “Proton-coupled conformational changes in photoreceptors”supported by the German Research Foundation (DFG) Host: Freie Universität Berlin http://www.sfb1078.de/ http://www.sfb1078.de/research/b6/index.html

Cluster of Excellence "Unifying Systems in Catalysis" (UniSysCat) - 2019-2025 UniSysCat Full Projects (3 as Principal Investigator) - Research units B/C/E: (1) “Structural elucidation on activation and coupling mechanisms of H2 oxidation and O2 reduction in O2-tolerant [NiFe]-hydrogenases and artificial bio-catalytic model hydrogenases” (2) "Structural basis of engineered rhodopsin-based light-gated enzyme systems for optogenetic and biocatalytic applications" (3) "Structural elucidation of light-controlled inositol polyphosphate kinase and other biocatalyst enzymes" Cluster of Excellence "Unifying Systems in Catalysis" supported by the German Research Foundation (DFG) Host: Technische Universität Berlin https://www.unisyscat.tu-berlin.de/

Collaborative Research Centre 1365 (SFB 1365) "Renoprotection" 2019-2022 First Period SFB 1365-A03 Full Project: “Renoprotection by understanding functional and structural G-protein-coupled receptor activation” supported by the German Research Foundation (DFG) Host: Charité Universitätsmedizin Berlin https://nephroprotektion.charite.de/en/

Collaborative Research Centre 1423 (SFB 1423) "Structural Dynamics of GPCR Activation and Signaling" 2020-2023 First Period SFB 1423-A01/A05/Z03 Full Project:s “Structural Dynamics of GPCR Activation and Signaling” supported by the German Research Foundation (DFG)

Collaborative Research Centre 1078 (SFB 1078) "Protonation Dynamics in Protein Function" 2017-2020 Second Period SFB 1078-B6 Full Project: “Proton-coupled conformational changes in photoreceptors” together with Prof. Peter Hildebrandt (TU-Berlin) supported by the German Research Foundation (DFG) Host: Freie Universität Berlin http://www.sfb1078.de/ http://www.sfb1078.de/research/b6/index.html

Collaborative Research Centre 740 (SFB 740) "From molecules to modules: Organisation and dynamics of functional units in cells" - 2015-2018 SFB 740-B6 Full Project: “Structural elucidation of the GPCR allosteric machine” together with Dr. Peter Hildebrand (Charité) supported by the German Research Foundation (DFG) Host: Charité - Universitätsmedizin Berlin http://www.sfb740.de/en/

Cluster of Excellence "Unifying Concepts in Catalysis" (UniCat) - 2012-2018 UniCat Full Projects - Research units E: “Protein X-ray crystallography of [NiFe] hydrogenase and other enzyms” Cluster of Excellence "Unifying Concepts in Catalysis" supported by the German Research Foundation (DFG) Host: Technische Universität Berlin https://www.unicat.tu-berlin.de/home/ https://www.unicat.tu-berlin.de/index.php?id=950