Osagie Obamwonyi

Research Scientist II - Drug Metabolism and Pharmacokinetics @ Novartis

Country

Switzerland

City

Basel

Industry

Pharmaceuticals

Skill

Overview of Drug Discovery and Development, Clinical Drug Development, Drug Discovery, Nonclinical Drug Development, Project Selection and Initiation, The Data Scientist’s Toolbox, Data Analytics, Ion Chromatography, GC-MS, Liquid Chromatography-Mass Spectrometry (LC-MS), Mass Spectrometry, Research, Risk Assessment, Exposure Assessment, Sales, Data Analysis, Laboratory Skills, High-Performance Liquid Chromatography (HPLC), Statistics, Cell Culture

Experience

Research Scientist II - Drug Metabolism and Pharmacokinetics

Novartis

2024-9 - Present · 2 yrs 1 mo

Basel, Switzerland

- In vitro ADME studies -Enzyme inhibition - Drug-Drug Interaction (DDI) liabilities investigations - Drug Metabolism and Enzyme Phenotyping - UPLC-MS/MS and LC-HR-MS , Radio-HPLC - Metabolic Stability - Drug route of elimination and pathway contribution - (Bio)analytics of Pharmaceuticals -Metabolite Identification - Data analysis and Data interpretation - Write study report for submission

Research Scientist II - Translational Profiling

Novartis

2022-8 - 2024-8 · 2 yrs 1 mo

Basel, Switzerland

-LC-MS/MS method development for small molecule analytics -Polar metabolites and lipid analysis -Energy metabolism and related pathways -First-hand experience with IC-MS/MS, UPLC/HPLC - MS with different mass analyzer - Orbitrap (Q-Exactive, Lumos) Sciex QTRAP 6500+, Q-TOF -Preclinical biomarker discovery and identification -Multi-omics approach in drug discovery and early drug development -Monitor metabolic pathways and screening endogenous biomarker in biological samples -MoA investigation for lead drug candidates

Analytical Chemist

vly

2022-5 - 2022-8 · 4 mos

Berlin, Germany

Non-target analysis of volatile aroma components of milk alternative, kakaodrink and yohgurt products using Solid Phase Microextraction-GC-MS. Task include but not limited to SPME-GC-MS method development, optimization, data analysis and interpretation

Research Assistant

University of Applied Sciences and Arts Northwestern Switzerland FHNW

2020-8 - 2022-5 · 1 yr 10 mos

Muttenz, Switerland

• Design experiment for biodegradation of volatile organics and pollutants • Develop GC/GC-MS and HPLC-UV/MS methods for qualitative and quantitative analysis of small polar molecules, volatile and non-volatile compounds, and their metabolites • Implementation of the designed experiment- Set up Anaerobic degradation and batch reactors • Identify and characterize metabolites generated during degradation processes by LC/QTOF and/or GC-FID/MS • Determination of mass balance pollutants and rate of degradation • Instrument’s maintenance and troubleshooting: HPLC, QQQ, QTOF (Agilent), GC-FID/MS (Agilent) • Write and review analytical method development • Provide guidance and coaching to interns and students.

Research Intern

Örebro University

2018-1 - 2018-8 · 8 mos

Orebro, Sweden

Mixture toxicity || Bioanalytics || Cell Culture || Risk Assessment Chemicals || Zebra Fish embryo acute toxicity test || in vivo assays || Data Analysis

Student Assistant

University of Duisburg-Essen

2016-6 - 2016-9 · 4 mos

Essen Area, Germany

• Sampling, measurement, and quantitative analysis of volcanic gases (Radon, Helium, CO2, O2 & CH4) from soil, mineral spring water, and ambient air • Water quality monitoring- pH, conductivity, temperature, DOM, sum parameters • Presentation and interpretation of data • Project management support – planning and logistics Main Techniques used: Mass spectrometer (MS), GC-MS, Radon detector –LUK4 and spectroscopy